16664-12-3Relevant academic research and scientific papers
Electrochemical Hofmann rearrangement mediated by NaBr: Practical access to bioactive carbamates
Li, Lijun,Xue, Mengyu,Yan, Xin,Liu, Wenmin,Xu, Kun,Zhang, Sheng
supporting information, p. 4615 - 4618 (2018/07/06)
An electrochemical Hofmann rearrangement is reported. With the mediation of NaBr, highly corrosive and toxic halogens are avoided. Moreover, this efficient and green approach is well compatible with a broad range of amides, including several commercial medicine derivatives, and provides direct access to synthetically useful carbamates. The synthetic utility of this method is also demonstrated by the preparation of 15N labeling carbamate and gram-scale synthesis of Amantadine.
A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
Palmieri, Alessandro,Ley, Steven V.,Hammond, Kelvin,Polyzos, Anastasios,Baxendale, Ian R.
scheme or table, p. 3287 - 3289 (2009/08/07)
We report on the use of commercially available chemical microreactors to effect the Hofmann rearrangement of aromatic amides to the corresponding carbamates. Crown Copyright
Efficient palladium/1,10-phenanthroline-catalyzed reductive carbonylation of mono- and dinitroarenes to urethanes in phosphonium salt ionic liquids
Yang, Qian,Robertson, Al,Alper, Howard
experimental part, p. 5079 - 5082 (2009/05/07)
(Chemical Equation Presented) The highly reactive and selective reductive carbonylation of mono- and dinitroarenes to the corresponding mono- and diurethanes was carried out in the presence of a PdCl2/Phen catalytic system, using PSIL110[C14H29(C6H 13)3P+PF6-] as the ionic liquid under mild reaction conditions. No cocatalyst is required.
