16667-76-8

Basic information

• Product Name: 8,2'β-Epithio-2'-deoxyadenosine
• Synonyms: (6aS)-4-Amino-6aα,7,8,9aα-tetrahydro-7α-hydroxyfuro[2',3':4,5]thiazolo[3,2-e]purine-8β-methanol;8,2'β-Epithio-2'-deoxyadenosine
• CAS NO: 16667-76-8
• Molecular Formula: C₁₀H₁₁N₅O₃S
• Molecular Weight: 281.29104
• Mol File: 16667-76-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8,2'β-Epithio-2'-deoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 8,2'β-Epithio-2'-deoxyadenosine(16667-76-8)
• EPA Substance Registry System: 8,2'β-Epithio-2'-deoxyadenosine(16667-76-8)

Safety Data

• Hazardous Substances Data: 16667-76-8(Hazardous Substances Data)

Upstream product

• 78086-10-9 pyridinium salt of 8,2'-S-cycloadenosine 3'-phosphate 
• 208402-30-6 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-8-mercaptoadenosine 
• 3001-45-4 6-amino-9-β-D-ribofuranosyl-7,9-dihydro-purine-8-thione 
• 10310-21-1 2-Amino-6-chloropurin 
• 34436-26-5 8-bromo-adenosine-2',3'-carbonate 
• 208402-31-7 8,2'-anhydro-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-8-mercaptoadenosine 
• 78039-48-2 8,2'-S-cycloadenylyl-(3'-5')-8,2'-S-cycloadenosine 
• 15715-58-9 triethylamine carbonate 
• 16667-73-5 8-bromo-2'-O-p-toluenesulfonyl adenosine 

Downstream Products

• 39030-42-7 (6aS)-4-benzoylamino-7c-benzoyloxy-8t-hydroxymethyl-(6ar,9ac)-6a,7,8,9a-tetrahydro-furo[2',3':4,5]thiazolo[3,2-e]purine 
• 56828-01-4 5'-O-monomethoxytrityl-8,2'-S-cycloadenosine 
• 57019-73-5 (6aS)-4-amino-8t-(toluene-4-sulfonyloxymethyl)-(6ar,9ac)-6a,7,8,9a-tetrahydro-furo[2',3':4,5]thiazolo[3,2-e]purin-7c-ol 
• 50560-03-7 (6aS)-4-benzoylamino-8t-(4-methoxy-trityloxymethyl)-(6ar,9ac)-6a,7,8,9a-tetrahydro-furo[2',3':4,5]thiazolo[3,2-e]purin-7c-ol 

Relevant articles and documents

New purine derivatives for efficient preparation of nucleoside analogs via alkylation

New diazabicycloundecenium and phosphazenium derivatives of purines are introduced for mild and efficient preparation of nucleoside analogs via in situ alkylation. Diazabicycloundecenium salts of purines were obtained directly as a result of an unusual reaction between two corresponding amino compounds.

Facile synthesis of 8,2'-S-cyclopurine nucleoside

This paper describes the synthesis of 8,2'-anhydro-8-mercapto-9-(β-D- arabinofuranosyl)purine (8,2'-S-cyclopurinenucleoside, 1) via the shorter route from 3',5'-di-O-acectyl-8,2'-S-cycloadenosine (6) and by direct reductive deamination with n-pentyl nitrite in tetrahydrofuran (THF) and deacetylation. The preparation of 8,2'-S-cycloadenosine (2) was achieved in good yield by the cyclization of the protected 8-mercaptoadenosine with triphenylphosphine and diethyl azodicarboxylate (DEAD) in THF at room temperature, under Mitsunobu reaction conditions.

Polynucleotides. LXI. Synthesis and properties of dinucleoside monophosphates containing 8,2'-S-cycloadenosine and 8,2'-S-cycloinosine residues. Sequence dependency of the stability of the stacking conformation

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