16667-76-8

Upstream product

• 15715-58-9 triethylamine carbonate 
• 78039-48-2 8,2'-S-cycloadenylyl-(3'-5')-8,2'-S-cycloadenosine 
• 34436-26-5 8-bromo-adenosine-2',3'-carbonate 
• 78086-10-9 pyridinium salt of 8,2'-S-cycloadenosine 3'-phosphate 
• 208402-30-6 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-8-mercaptoadenosine 
• 3001-45-4 6-amino-9-β-D-ribofuranosyl-7,9-dihydro-purine-8-thione 
• 10310-21-1 2-Amino-6-chloropurin 
• 208402-31-7 8,2'-anhydro-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-8-mercaptoadenosine 
• 16667-73-5 8-bromo-2'-O-p-toluenesulfonyl adenosine 

Downstream Products

• 39030-42-7 (6aS)-4-benzoylamino-7c-benzoyloxy-8t-hydroxymethyl-(6ar,9ac)-6a,7,8,9a-tetrahydro-furo[2',3':4,5]thiazolo[3,2-e]purine 
• 56828-01-4 5'-O-monomethoxytrityl-8,2'-S-cycloadenosine 
• 57019-73-5 (6aS)-4-amino-8t-(toluene-4-sulfonyloxymethyl)-(6ar,9ac)-6a,7,8,9a-tetrahydro-furo[2',3':4,5]thiazolo[3,2-e]purin-7c-ol 
• 50560-03-7 (6aS)-4-benzoylamino-8t-(4-methoxy-trityloxymethyl)-(6ar,9ac)-6a,7,8,9a-tetrahydro-furo[2',3':4,5]thiazolo[3,2-e]purin-7c-ol 

Relevant academic research and scientific papers

New purine derivatives for efficient preparation of nucleoside analogs via alkylation

New diazabicycloundecenium and phosphazenium derivatives of purines are introduced for mild and efficient preparation of nucleoside analogs via in situ alkylation. Diazabicycloundecenium salts of purines were obtained directly as a result of an unusual reaction between two corresponding amino compounds.

The synthesis of cyclonucleotides with fixed glycosidic bond linkages as putative agonists for P2-purinergic receptors

Cyclonucleotides with fixed glycosidic bond linkages were investigated as possible ligands for purinoceptors in PC12 cells. P2Y2-purinoceptors were not activated by the ATP analogue, 8,2'-thioanhydroadenosine-5'-triphosphate (4) and only weakly

Facile synthesis of 8,2'-S-cyclopurine nucleoside

This paper describes the synthesis of 8,2'-anhydro-8-mercapto-9-(β-D- arabinofuranosyl)purine (8,2'-S-cyclopurinenucleoside, 1) via the shorter route from 3',5'-di-O-acectyl-8,2'-S-cycloadenosine (6) and by direct reductive deamination with n-pentyl nitrite in tetrahydrofuran (THF) and deacetylation. The preparation of 8,2'-S-cycloadenosine (2) was achieved in good yield by the cyclization of the protected 8-mercaptoadenosine with triphenylphosphine and diethyl azodicarboxylate (DEAD) in THF at room temperature, under Mitsunobu reaction conditions.