166773-38-2Relevant academic research and scientific papers
Synthesis and reactions of (2-methylquinazol-4-oxy) acetic acid hydrazide
Wasfy, A. A. F.,Yassin, F. A.,Eissa, A. M. F.
, p. 537 - 539 (2007/10/02)
(2-Methylquinazol-4-oxy) acetic acid hydrazide (3) reacts with appropriate aldehydes and ketone to give the corresponding hydrazone derivatives (4a-c and 6) which are subsequently cyclised to 4-thiazolidinone (5a-c) and pyrazole derivatives (7), respectively.Also, the cyclization of the hydrazide 3 with acetonylacetone yield pyrrole derivative 8.Reaction of 3 with phenyl isothiocyanate and/or phenyl isocyanate in different solvents produced S-triazole (9), thiosemicarbazide and semicarbazide derivatives (10a,b), respectively.Compounds 10a,b are susceptible to ring-closure on treatment with phenacyl bromide leading to thiazole and oxazole derivatives (11a,b).
