1769-24-0Relevant articles and documents
Aluminium-containing ring systems and N-heterocycle formation via nitrile insertions into Al-N bonds
Gibson,Redshaw,White,Williams
, p. 79 - 80 (2001)
Reactions of Me3Al with 1,2-diaminobenzene [1,2-(H2N)2C6H4] or anthranilic acid, [1,2-(H2N)(HO2-C)C6H4], followed by treatment with acetonitrile, afford tetranuclear and hexanuclear aluminium-containing ring systems; a single crystal X-ray structure on the hexametallic product reveals the construction of quinazoline ligands arising via insertion of acetonitrile into Al-N bonds.
Infrared spectra, thermogravimetric analysis and antifungal studies of noval cr(iii), fe(iii) and cu(ii) 2-methyl-quinazolinone complexes
Sadeek,El-Attar,El-Lattif, N.S. Abd
, p. 53 - 66 (2014)
Some new solid complexes [CrCl3(L)3]×6H 23O, [FeCl3(L)3]×6H2O and [Cu(CH 3COO)2(L)3]×2H2O have been synthesized quantitatively by the interactions of 2-methyl-quinazolinone (L) with CrCl3.6H23O, FeCl3.6H2O and Cu(CH3COO)2. 2H2O in a mixture of an ethanol-bidistilled water (1:1), at 60 °C. They were characterized by melting point, molar conductivity, magnetic moment, elemental analysis, infrared spectra and thermal analyses. The results supported the formation of the complexes and indicated that the ligand reacted as a monodentate ligand bound to the metal ion through the oxygen atom. The antifungal activity of the free ligand and their metal complexes were evaluated against several species, such as Fusarium solani, Rizoctonia solani, Sclortium rolfsii and Botryodiplodia and they showed a good antifungal activity to some selected fungal strain as compared with free ligand.
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Siegle,Christensen
, p. 5777 (1951)
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Acylanthranils. 9. Influence of Hydrogen Bonding on the Reaction of Acetylanthranil with Ammonia
Errede, L. A.,Martinucci, P. D.,McBrady, J. J.
, p. 3009 - 3017 (1980)
It was shown that hydrogen bonding has a marked influence on the reaction of acetylanthranil (1) with ammonia.The product of the reaction in anhydrous benzene is 2-methylquinazolin-4-one (5, R = H) which is formed via pathway A as shown in Scheme I, but the rate of formation is unusually slow.The rate of this conversion is about 6 times faster in pyridine than in benzene.If water is added to the benzene system, the rate of reaction is increased by orders of magnitude, but the product is o-acetamidobenzamide (4, R = H) and not 5.In contrast to this result, the addition of water to the pyridine system causes a small decrease in rate and only a slight change in selectivity.These results are consistent with postulated mechanisms whereby 1 reacts with molecular clusters of ammonia, i.e. with (NH3)n in benzene, with N(H*S)3 in strong proton acceptor solvents S, and with (NH3)n*H2O in benzene plus added water.It was verified that cyclodehydration of 4 to give 5 occurs at an appreciable rate in aqueous solution at elevated temperatures and that this rate is accelerated considerably by the presence of strong base even at room temperature.It was also observed that o-acetamidobenzamide exists in at least two crystalline forms, α and β, which have different physical properties.
Unexpected Products from Carbonylation of Lithiated Quinazolin-4(3H)-one Derivatives
Smith,El-Hiti,Abdel-Megeed
, p. 430 - 435 (2003)
Doubly lithiated 3-pivaloylaminoquinazolin-4(3H)-one reacts with carbon(II) oxide at 0°C to give 77% of a mixture of azetidinone and indole derivatives, each incorporating a diisopropylamide unit from lithium diisopropylamide used for lithiation. No analogous reaction occurs with doubly lithiated 3-acetyl-aminoquinazolin-4(3H)-one and 3-acyl-2-alkylquinazolin-4(3H)- one. Carbonylation of doubly lithiated 2-alkyl-3-aminoquinazolin-4(3H)-ones at 0°C results in deamination to give 2-alkylquinazolin-4(3H)-ones in good yields.
Heterocyclic compounds; IX. A facile synthesis of methaqualone and analogs
Manhas,Amin,Rao
, p. 309 - 310 (1977)
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Method for preparing quinazolone and derivatives thereof by using chitosan-loaded copper catalyst
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Paragraph 0031-0038, (2021/05/12)
The invention discloses a method for preparing quinazolone and derivatives thereof by using a chitosan-loaded copper catalyst, which comprises the following steps of replacing residual gas in a reaction container with inert gas, adding a catalytic amount of copper ion-loaded chitosan catalyst, substituted 2-halogenated benzoic acid, substituted amidine hydrochloride, inorganic alkali and a mixed solvent into the reaction container, and heating for reaction, after the reaction time is 2-18 hours, extracting the product by using ethyl acetate, filtering and recovering the copper ion-loaded chitosan catalyst, concentrating the filtrate under reduced pressure, and purifying the product by column chromatography. The method has the advantages of low catalyst dosage, recoverability, easy separation after reaction, no metal residue, simple post-treatment, and suitableness for large-scale production.
Method for photocatalytic synthesis of quinazolinone
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Paragraph 0041-0042, (2021/07/31)
The invention discloses a method for photocatalytic synthesis of quinazolinone. Anthranilamide and aldehyde are used as raw materials, fluorescein is used as a photocatalyst, p-toluene sulfonic acid is used as an auxiliary catalyst, and the quinazolinone is obtained through photocatalytic reaction under the irradiation of visible light. The non-metal catalyst is used, so that the reaction cost is reduced; the reaction conditions are mild, and the reaction can be completed at room temperature; and the method is simple to operate, short in reaction time, simple in post-treatment, high in product yield and more environment-friendly. The method not only has high academic value, but also has a certain industrialization prospect.
