1668-99-1

Basic information

• Product Name: (9S)-6'-methoxycinchonan-9-ol monohydrochloride
• Synonyms: (9S)-6'-methoxycinchonan-9-ol monohydrochloride
• CAS NO: 1668-99-1
• Molecular Formula: C₂₀H₂₄N₂O₂*ClH
• Molecular Weight: 360.8777
• EINECS: 216-792-8
• Mol File: 1668-99-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 495.9°Cat760mmHg
• Flash Point: 253.7°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: (9S)-6'-methoxycinchonan-9-ol monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (9S)-6'-methoxycinchonan-9-ol monohydrochloride(1668-99-1)
• EPA Substance Registry System: (9S)-6'-methoxycinchonan-9-ol monohydrochloride(1668-99-1)

Safety Data

• Hazardous Substances Data: 1668-99-1(Hazardous Substances Data)

Usage

General Description

"(9S)-6'-methoxycinchonan-9-ol monohydrochloride" is a chemical compound that belongs to the cinchona alkaloids family. It is a derivative of quinine, which is a medication used to treat malaria. (9S)-6'-methoxycinchonan-9-ol monohydrochloride is a chiral molecule, meaning it has a non-superimposable mirror image, and the "(9S)" designation specifies its stereochemistry. The presence of the hydrochloride group indicates that it is a salt form of the compound, which can influence its solubility and stability. The methoxy group in its structure also gives it unique chemical properties. Overall, "(9S)-6'-methoxycinchonan-9-ol monohydrochloride" has potential pharmaceutical applications due to its similarity to quinine and its specific chemical structure.

Upstream product

• 130-95-0 Quinine 
• 121-54-0 benzethonium cloride 
• 56-54-2 quinine 
• 115-39-9 bromophenol blue 
• 76-60-8 bromocresol green 

Downstream Products

• 522-66-7 dihydroquinine 

Relevant articles and documents

Multiple-responsive ionic complex luminogen of quinine and camphorsulfonic acid with aggregation-induced emission

Bulky camphorsulfonic acid (CSA) was used to complex with quinine (Qu) to impose restricted intramolecular rotation (RIR) required for aggregation-induced emission (AIE) properties. After complexation with two equivalents of CSA, the non-emissive quinine (Qu) base can be protonated to produce an ionic complex Qu(CSA)2 with AIE properties. The ionic bonds in the complex Qu(CSA)2 are sensitive to various external stimuli, which allows its use as a luminescent sensor for pH values and different metal ions. Moreover, the ionic Qu(CSA)2 can be a denaturant and biological sensor for the blood protein of bovine serum albumin (BSA); through the use of Qu(CSA)2, the unfolding process of the BSA chains was evaluated. Theoretical and practical aspects of this ionic Qu(CSA)2 complex are discussed in this study.

Substitution reactions of benzethonium chloride with ion associates of bromocresol green - quinine and bromophenol blue - quinine in dichlormethane

An excess concentration of base quinine (Q) reacts with a sulphonphthalein diacidic dye XH2, (bromocresol green, BCGH2, or bromophenol blue, BPBH2) in dichlormethane solution to form an ion associate (X(2-)(QH21+)2) of stoichiometry 1:2 (dye:amine).Benzethonium chloride (CIB) reacts with the 1:2 ion associate to form an ion associate (QH1+,X2-,B1+) and quinine hydrochloride ClQH(1+).This substitution reaction is a chemical equilibrium with formation constants of 1.50+/-0.67, 1.64+/-0.54, 1.07+/-0.29, 1.04+/-0.20, and 0.84+/-0.26 for BCG and 1.86+/-0.59, 1.47+/-0.23, 1.40+/-0.65, 1.13+/-0.37, and 1.11+/-0.27 for BPB at 283.16, 288.16, 293.16, 298.16, and 303.16 K respectively.The thermodynamic parameters determined by van't Hoff's equation are ΔH0 = -21.766+/-7.482 kJmol-1, ΔS0 = -73+/-51 Jmol-1K-1, and ΔG0 = -1.134+/-0.972 kJmol-1 for BCG and ΔH0 = -18.678+/-7.482 kJmol-1, ΔS0 = -61+/-26 Jmol-1K-1, ΔG0 = -0.916+/-0.401 kJmol-1 for BPB (ΔG0 at 293.16K; and ΔH0 and ΔS0 determined in the range 283-303K). Key words: bromocresol green-quinine-benzetonium, ion associate mixture, bromophenol blue-quinine-benzethonium, equilibrium constants, thermodynamic parameters.