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121-54-0 Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 121-54-0 differently. You can refer to the following data:
1. White or yellowish-white powder.
2. Benzethonium chloride occurs as a white crystalline material with a mild odor and very bitter taste.

Originator

Phemerol,Parke Davis,US,1942

Uses

Different sources of media describe the Uses of 121-54-0 differently. You can refer to the following data:
1. benzethonium chloride is a preservative that works against algae, bacteria, and fungi. In skin care preparations, it is safe for use at concentrations of 0.5 percent.
2. antiinfective (topical)
3. A synthetic quaternary ammonium salt with surfactant, antiseptic and anti-infective properties. It exhibits microbiocidal activity against a broad range of bacteria, fungi, mold and viruses. It has al so been found to have significant broad-spectrum anticancer activity.
4. In cosmetics as preservative; cationic surfactant. As disinfectant in dairies and food industries. Clinical reagent for determination of protein in CSF; pharmaceutic aid (preservative).
5. Benzethonium Chloride USP is used as germicide for pharmaceutical and cosmetic products. (USP grade of Hyamine(R) 1622 crystals).
6. The cationic detergent benzethonium chloride is a well characterized skin irritant and rare sensitizer. Benzethonium chloride has been used in a study to assess the minimum inhibitory concentrations of meticillin-resistant Staphylococcus aureus (MRSA) isolates from Malaysia. It has also been used in a study to prepare biocomposite films from sodium alginate and modified clay.
7. Hyamine(R) 1622 Crystals is a FDA accepted ingredient for topical applications. It can be used as a bactericide, deodorant, or as a preservative in various applications including those in personal care, veterinary and pharmaceutical.

Definition

ChEBI: A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it i active against a broad spectrum of bacteria, fungi, moulds and viruses.

Production Methods

p-Diisobutylphenol is condensed in the presence of a basic catalyst with β,β'-dichlorodiethyl ether to yield 2-[2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination then produces the corresponding tertiary amine which, after purification by distillation, is dissolved in a suitable organic solvent and treated with benzyl chloride to precipitate benzethonium chloride.

Manufacturing Process

A mixture of 32 g of p-(α,α,γ,γ-tetramethylbutyl)phenoxyethoxyethyldimethylamine and 12.7 parts of benzyl chloride was warmed in 50 g of benzene for 2 hours. The benzene was then evaporated. The residual viscous mass gave a foamy, soapy solution in water. The original starting materials are p-diisobutylphenol, dichlorodiethyl ether and dimethylamine.

Brand name

Microklenz (Carrington); Phemerol Chloride (Parke-Davis).

Therapeutic Function

Topical antiinfective

General Description

Odorless white crystals or powder with a very bitter taste. A 1% solution in water is slightly alkaline to litmus.

Air & Water Reactions

Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble.

Reactivity Profile

Benzethonium chloride is incompatible with strong oxidizing agents Incompatible with soap and anionic detergents. Can react with nitrates. Sensitive to light. Acids cause Benzethonium chloride to precipitate from aqueous solutions of >2% concentration. Stable for two weeks at temperatures up to 140 F, .

Hazard

An oral poison.

Fire Hazard

Flash point data for Benzethonium chloride are not available. Benzethonium chloride is probably combustible.

Flammability and Explosibility

Notclassified

Pharmaceutical Applications

Benzethonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative. Typically, it is used for this purpose in injections, ophthalmic and otic preparations at concentrations 0.01–0.02% w/v. Benzethonium chloride may also be used as a wetting and solubilizing agent, and as a topical disinfectant. In cosmetics such as deodorants, benzethonium chloride may be used as an antimicrobial preservative in concentrations up to 0.5% w/v. The physical properties and applications of benzethonium chloride are similar to those of other cationic surfactants such as cetrimide.

Safety Profile

Poison by ingestion,subcutaneous, intraperitoneal, and intravenous routes. Asevere eye irritant. Questionable carcinogen withexperimental neoplastigenic data. Mutation data reported.When heated to decomposition it emits very toxic fumesof Cl -

Safety

Benzethonium chloride is readily absorbed and is generally regarded as a toxic substance when administered orally. Ingestion may cause vomiting, collapse, convulsions, and coma. The probable lethal human oral dose is estimated to be 50–500 mg/kg bodyweight. The topical use of solutions containing greater than 5% w/v benzethonium chloride can cause irritation although benzethonium chloride is not regarded as a sensitizer. The use of 0.5% w/v benzethonium chloride in cosmetics is associated with few adverse effects. A maximum concentration of 0.02% w/v benzethonium chloride is recommended for use in cosmetics used in the eye area and this is also the maximum concentration generally used in pharmaceutical formulations such as injections and ophthalmic preparations. See also Benzalkonium Chloride. LD50 (mouse, IP): 15.5 mg/kg LD50 (mouse, IV): 30 mg/kg LD50 (mouse, oral): 338 mg/kg LD50 (rat, IP): 16.5 mg/kg LD50 (rat, IV): 19 mg/kg LD50 (rat, oral): 368 mg/kg LD50 (rat, SC): 119 mg/kg

storage

Benzethonium chloride is stable. Aqueous solutions may be sterilized by autoclaving. The bulk material should be stored in an airtight container protected from light, in a cool, dry place.

Purification Methods

Crystallise it from boiling acetone after filtering or from CHCl3/pet ether. The precipitate is filtered off, washed with diethyl ether and dried for 24hours in a vacuum desiccator. It is a cationic antiseptic surfactant which forms crystals also from a 1:9 MeOH/Et2O mixture. It foams in water. [Beilstein 12 IV 2187.]

Incompatibilities

Benzethonium chloride is incompatible with soaps and other anionic surfactants and may be precipitated from solutions greater than 2% w/v concentration by the addition of mineral acids and some salt solutions.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM and IV injections; nasal, ophthalmic and otic preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Check Digit Verification of cas no

The CAS Registry Mumber 121-54-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 121-54:
(5*1)+(4*2)+(3*1)+(2*5)+(1*4)=30
30 % 10 = 0
So 121-54-0 is a valid CAS Registry Number.
InChI:InChI=1/C27H42NO2.ClH/c1-26(2,3)22-27(4,5)24-13-15-25(16-14-24)30-20-19-29-18-17-28(6,7)21-23-11-9-8-10-12-23;/h8-16H,17-22H2,1-7H3;1H/q+1;/p-1

121-54-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A16142)  Benzethonium chloride, 97%   

  • 121-54-0

  • 100g

  • 346.0CNY

  • Detail
  • Alfa Aesar

  • (A16142)  Benzethonium chloride, 97%   

  • 121-54-0

  • 500g

  • 1258.0CNY

  • Detail
  • Alfa Aesar

  • (A16142)  Benzethonium chloride, 97%   

  • 121-54-0

  • 2500g

  • 5039.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1425)  Benzethonium Chloride  pharmaceutical secondary standard; traceable to USP, PhEur

  • 121-54-0

  • PHR1425-1G

  • 791.15CNY

  • Detail
  • Sigma-Aldrich

  • (B0550000)  Benzethoniumchloride  European Pharmacopoeia (EP) Reference Standard

  • 121-54-0

  • B0550000

  • 1,880.19CNY

  • Detail
  • USP

  • (1051500)  Benzethoniumchloride  United States Pharmacopeia (USP) Reference Standard

  • 121-54-0

  • 1051500-500MG

  • 4,662.45CNY

  • Detail
  • Aldrich

  • (51126)  Hyamine®1622solution  4 mM in H2O

  • 121-54-0

  • 51126-1L-F

  • 510.12CNY

  • Detail
  • Aldrich

  • (51126)  Hyamine®1622solution  4 mM in H2O

  • 121-54-0

  • 51126-5L-F

  • 2,012.40CNY

  • Detail
  • Sigma-Aldrich

  • (70585)  Benzethoniumchloride  tested according to USP

  • 121-54-0

  • 70585-250G-F

  • 3,305.25CNY

  • Detail
  • Sigma-Aldrich

  • (70585)  Benzethoniumchloride  tested according to USP

  • 121-54-0

  • 70585-1KG-F

  • 11,115.00CNY

  • Detail
  • Sigma

  • (53751)  Benzethoniumchloride  BioUltra, ≥99.0% (AT)

  • 121-54-0

  • 53751-50G

  • 1,229.67CNY

  • Detail
  • Sigma

  • (53751)  Benzethoniumchloride  BioUltra, ≥99.0% (AT)

  • 121-54-0

  • 53751-250G

  • 4,533.75CNY

  • Detail

121-54-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name benzethonium chloride

1.2 Other means of identification

Product number -
Other names HYAMINE 1622, REAG

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:121-54-0 SDS

121-54-0Synthetic route

(p-tert-octylphenoxyethoxyethyl)dimethylamine
5442-83-1

(p-tert-octylphenoxyethoxyethyl)dimethylamine

benzyl chloride
100-44-7

benzyl chloride

benzethonium cloride
121-54-0

benzethonium cloride

Conditions
ConditionsYield
With benzene
for 2h; Solvent; Reagent/catalyst; Reflux;172.7 g
With 4-methyl-2-pentanone for 2h; Solvent; Temperature; Reagent/catalyst; Reflux;172.7 g
Conditions
ConditionsYield
In dichloromethane Equilibrium constant;
Conditions
ConditionsYield
In dichloromethane Equilibrium constant;
tert-octylphenol
140-66-9

tert-octylphenol

benzethonium cloride
121-54-0

benzethonium cloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaOH; water / 110 - 120 °C
2: 180 °C
3: benzene
View Scheme
Multi-step reaction with 3 steps
1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; toluene / 110 °C
2: N-benzyl-N,N,N-triethylammonium chloride / water / 3 h / 160 °C / Sealed tube
3: 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: potassium hydroxide; tetrabutylammomium bromide / 1-methyl-pyrrolidin-2-one; water / 205 °C
2: tetrabutylammomium bromide / water / 5 h / 130 °C / Sealed tube
3: 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; toluene / 5 h / 110 °C
2: N-benzyl-N,N,N-triethylammonium chloride / water / 3 h / 160 °C / Sealed tube
3: 4-methyl-2-pentanone / 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: potassium hydroxide; tetrabutylammomium bromide / 1-methyl-pyrrolidin-2-one; water / 8 h / 205 °C
2: tetrabutylammomium bromide / water / 5 h / 130 °C / Sealed tube
3: 4-methyl-2-pentanone / 2 h / Reflux
View Scheme
1-[2-(2-chloroethoxy)ethoxy]-4-(1,1,3,3-tetramethylbutyl)benzene
65925-28-2

1-[2-(2-chloroethoxy)ethoxy]-4-(1,1,3,3-tetramethylbutyl)benzene

benzethonium cloride
121-54-0

benzethonium cloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 180 °C
2: benzene
View Scheme
Multi-step reaction with 2 steps
1: N-benzyl-N,N,N-triethylammonium chloride / water / 3 h / 160 °C / Sealed tube
2: 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: N-benzyl-N,N,N-triethylammonium chloride / water / 3 h / 160 °C / Sealed tube
2: 4-methyl-2-pentanone / 2 h / Reflux
View Scheme
p-tert-octylphenoxyethoxyethyl bromide
1428422-45-0

p-tert-octylphenoxyethoxyethyl bromide

benzethonium cloride
121-54-0

benzethonium cloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide / water / 5 h / 130 °C / Sealed tube
2: 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide / water / 5 h / 130 °C / Sealed tube
2: 4-methyl-2-pentanone / 2 h / Reflux
View Scheme
LMWH benzyl ester sodium salt

LMWH benzyl ester sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

LMWH benzyl ester benzethonium salt

LMWH benzyl ester benzethonium salt

Conditions
ConditionsYield
In water at 19 - 25℃; for 1h;100%
In water at 20℃; for 1h;99%
In water at 20℃; for 1h;98%
benzethonium cloride
121-54-0

benzethonium cloride

hyaluronic acid sodium salt

hyaluronic acid sodium salt

hyaluronic acid benzethonium salt

hyaluronic acid benzethonium salt

Conditions
ConditionsYield
In water for 2.33333h;100%
carboxyl-reduced dermatan sulfate sodium salt

carboxyl-reduced dermatan sulfate sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

carboxyl-reduced dermatan sulfate benzethonium salt

carboxyl-reduced dermatan sulfate benzethonium salt

Conditions
ConditionsYield
In water100%
benzethonium cloride
121-54-0

benzethonium cloride

rac-Potassium mandelate
84864-61-9

rac-Potassium mandelate

benzyldimethyl(2-{2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl)ammonium mandelate

benzyldimethyl(2-{2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl)ammonium mandelate

Conditions
ConditionsYield
In water at 60℃; for 6h;99%
6-O-sulfated carboxyl-reduced chondroitin sulfate sodium salt

6-O-sulfated carboxyl-reduced chondroitin sulfate sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

6-O-sulfated carboxyl-reduced chondroitin sulfate benzethonium salt

6-O-sulfated carboxyl-reduced chondroitin sulfate benzethonium salt

Conditions
ConditionsYield
In water at 20℃; for 1h;96%
carboxyl-reduced chondroitin sulfate sodium salt

carboxyl-reduced chondroitin sulfate sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

carboxyl-reduced chondroitin sulfate benzethonium salt

carboxyl-reduced chondroitin sulfate benzethonium salt

Conditions
ConditionsYield
In water96%
aluminum (III) chloride
7446-70-0, 7784-13-6

aluminum (III) chloride

benzethonium cloride
121-54-0

benzethonium cloride

benzethonium tetrachloroaluminate

benzethonium tetrachloroaluminate

Conditions
ConditionsYield
In methanol at 40℃; for 4h;96%
heparin benzyl ester, sodium salt

heparin benzyl ester, sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

heparin benzyl ester, benzethonium salt

heparin benzyl ester, benzethonium salt

Conditions
ConditionsYield
In water at 20℃; for 12.58h;94.9%
heparin benzyl ester sodium salt

heparin benzyl ester sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

benzyl heparinate benzethonium salt

benzyl heparinate benzethonium salt

Conditions
ConditionsYield
Stage #1: heparin benzyl ester sodium salt In water at 20℃;
Stage #2: benzethonium cloride In water for 13.4167h;
94.9%
chondroitin sulfate sodium salt

chondroitin sulfate sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

chondroitin sulfate benzethonium salt

chondroitin sulfate benzethonium salt

Conditions
ConditionsYield
In water at 20℃;94%
dermatan sulfate sodium salt

dermatan sulfate sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

dermatan sulfate benzethonium salt

dermatan sulfate benzethonium salt

Conditions
ConditionsYield
In water94%
low molecular weight heparin sodium salt

low molecular weight heparin sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

LMWH benzethonium salt

LMWH benzethonium salt

Conditions
ConditionsYield
In water at 20℃; for 1h;89%
In water at 20℃; for 1h;87%
sodium salicylate
54-21-7

sodium salicylate

benzethonium cloride
121-54-0

benzethonium cloride

benzethonium salicylate
1220976-08-8

benzethonium salicylate

Conditions
ConditionsYield
In water; acetone at 20℃;87%
In water; acetone at 20℃;
6-O-sulfated carboxyl-reduced dermatan sulfate sodium salt

6-O-sulfated carboxyl-reduced dermatan sulfate sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

carboxyl-reduced 6-O-sulfated dermatan sulfate benzethonium salt

carboxyl-reduced 6-O-sulfated dermatan sulfate benzethonium salt

Conditions
ConditionsYield
In water84%
benzethonium cloride
121-54-0

benzethonium cloride

aspirin
50-78-2

aspirin

benzethonium acetylsalicylate
1344649-43-9

benzethonium acetylsalicylate

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone at 0℃;82%
persulfated carboxyl-reduced dermatan sulfate sodium salt

persulfated carboxyl-reduced dermatan sulfate sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

persulfated carboxyl-reduced dermatan sulfate benzethonium salt

persulfated carboxyl-reduced dermatan sulfate benzethonium salt

Conditions
ConditionsYield
In water81%
persulfated carboxyl-reduced chondroitin sulfate sodium salt

persulfated carboxyl-reduced chondroitin sulfate sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

persulfated carboxyl-reduced chondroitin sulfate benzethonium salt

persulfated carboxyl-reduced chondroitin sulfate benzethonium salt

Conditions
ConditionsYield
In water at 20℃; for 1h;80%
persulfated hyaluronic acid sodium salt

persulfated hyaluronic acid sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

persulfated hyaluronic acid benzethonium salt

persulfated hyaluronic acid benzethonium salt

Conditions
ConditionsYield
In water80%
3,6-dichloro-O-anisic acid
1918-00-9

3,6-dichloro-O-anisic acid

benzethonium cloride
121-54-0

benzethonium cloride

benzethonium 3,6-dichloro-2-methoxybenzoate
1354726-22-9

benzethonium 3,6-dichloro-2-methoxybenzoate

Conditions
ConditionsYield
With sodium hydroxide In water at 20 - 50℃; for 20h;75%
persulfated, carboxyl-reduced hyaluronic acid sodium salt

persulfated, carboxyl-reduced hyaluronic acid sodium salt

benzethonium cloride
121-54-0

benzethonium cloride

persulfated, carboxyl-reduced hyaluronic acid benzethonium salt

persulfated, carboxyl-reduced hyaluronic acid benzethonium salt

Conditions
ConditionsYield
In water69%
hydroxygallium naphthalocyaninetetrasulfonic acid

hydroxygallium naphthalocyaninetetrasulfonic acid

benzethonium cloride
121-54-0

benzethonium cloride

4C27H42NO2(1+)*C48H21GaN8O13S4(4-)

4C27H42NO2(1+)*C48H21GaN8O13S4(4-)

Conditions
ConditionsYield
In methanol; water Heating / reflux;63%
hydroxygallium naphthalocyaninetetrasulfonic acid

hydroxygallium naphthalocyaninetetrasulfonic acid

benzethonium cloride
121-54-0

benzethonium cloride

4C27H42NO2(1+)*C48H21GaN8O13S4(4-)

4C27H42NO2(1+)*C48H21GaN8O13S4(4-)

Conditions
ConditionsYield
In methanol; water63%
benzethonium cloride
121-54-0

benzethonium cloride

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

N-(3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-N,N-dimethyl-2-(2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)ethoxy)ethan-1-aminium chloride

N-(3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-N,N-dimethyl-2-(2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)ethoxy)ethan-1-aminium chloride

Conditions
ConditionsYield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; tetrabutylammonium (5'-methyl-[2,2'-bipyridin]-5-yl)methanesulfonate In tetrahydrofuran at 50℃; for 20h; Inert atmosphere; regioselective reaction;60%
Conditions
ConditionsYield
In dichloromethane Equilibrium constant; Thermodynamic data; ΔH0, ΔS0, ΔG0;
Conditions
ConditionsYield
In dichloromethane Equilibrium constant; Thermodynamic data; ΔH0, ΔS0, ΔG0;

121-54-0Related news

Determination of Benzethonium chloride (cas 121-54-0) in anthrax vaccine adsorbed by HPLC09/24/2019

A novel and sensitive HPLC method for the determination of benzethonium chloride (BZC) in anthrax vaccine was developed. Adjuvant Alhydrogel was removed by syringe filter after a simple sample pretreatment—acidification prior to injection. Chromatography was performed by isocratic reverse phase...detailed

Chemically modified carbon paste and membrane sensors for the determination of Benzethonium chloride (cas 121-54-0) and some anionic surfactants (SLES, SDS, and LABSA): Characterization using SEM and AFM09/08/2019

Chemically modified carbon-paste (CMCP) and membrane- sensors based on incorporating benzothonium-tetraphenylborate (BT-TPB) were constructed for the analysis of benzethonium chloride, and some other surfactants such as sodium lauryl ether sulphate (SLES), sodium dodecyl sulphate (SDS), and line...detailed

Theoretical and cyclic voltammetric studies on electrocatalysis of Benzethonium chloride (cas 121-54-0) at carbon paste electrode for detection of dopamine in presence of ascorbic acid09/07/2019

In the past decade, many surfactants have been used to modify carbon electrode to sense dopamine (DA). Even though plenty of works are already available on this strategy, still analyzing DA and ascorbic acid (AA) by surfactant modification is exciting and unfortunately, molecular level understan...detailed

Studies on the interactions of some small biomolecules with antibacterial drug Benzethonium chloride (cas 121-54-0) and its active pharmaceutical ingredient ionic liquid (API-IL) benzethonium L-proline at varying temperatures09/06/2019

From the conductivity, density and spectroscopy measurements, the interactions of benzethonium chloride ([BTC]) and its active pharmaceutical ingredient in ionic liquid format benzethonium L-proline ([BT][PRO]) with some amino acids and glycyl dipeptides have been examined. A number of useful pa...detailed

Clove bud essential oil emulsion containing Benzethonium chloride (cas 121-54-0) inactivates Salmonella Typhimurium and Listeria monocytogenes on fresh-cut pak choi during modified atmosphere storage09/05/2019

In this study, positively charged clove bud essential oil (CB)/benzethonium chloride (BEC) emulsion (CBB, 0.02% CB + 0.002% BEC) was used to inactivate Salmonella Typhimurium and Listeria monocytogenes inoculated on fresh-cut pak choi (FCPC). CBB treatment reduced the populations of S. Typhimuri...detailed

121-54-0Relevant articles and documents

METHOD FOR PREPARING ARYL POLYOXY ALKYL QUATERNARY AMMONIUM COMPOUND

-

, (2014/03/25)

A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R1 is H or a C1 to C16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R2 is H or a C1 to C16 alkyl group; R3 is H or a C1 to C16 alkyl group; R4 is a C1 to C16 alkyl group; X1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

NOVEL FORMULATION OF DEHYDRATED LIPID VESICLES FOR CONTROLLED RELEASE OF ACTIVE PHARMACEUTICAL INGREDIENT VIA INHALATION

-

, (2009/03/07)

A new formulation of dehydrated lipid vesicles employs a vesicle preserver and permits the control of release and delivery of active pharmaceutical ingredients into the respiratory system for treatment in particular of asthma. The typical formulation provides controlled release of the active pharmaceutical ingredient from 0% to 100% from 0 to 72 hours after inhalation, changes the systemic administration to topical administration, allows prolonged therapeutic period for one administration, increased stability, with reduced dose, reduced systemic side effects, reduced toxicity.

Fungicidal and bactericidal method

-

, (2008/06/13)

A fungicidal and bactericidal method of imparting fungicidal and bactericidal properties to an article by coating or impregnating the article with a solution of a quaternary ammonium salt of alginic acid or carboxymethyl cellulose (which is insoluble or sparingly soluble in water) in an organic solvent and thereafter removing the solvent from the article.

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