166820-34-4

Upstream product

• 100159-47-5 1-(benzyloxy)pyrazole 
• 100-39-0 benzyl bromide 

Downstream Products

• 936566-90-4 1-benzyloxy-5-bromo-4-iodopyrazole 
• 947672-68-6 (RS)-2-(1-benzyloxy-5-bromo-4-pyrazolyl)-2-(N-tert-butoxycarbonylamino)acetic acid 
• 936566-78-8 (RS)-2-(1-benzyloxy-5-bromo-4-pyrazolyl)-2-(N-tert-butoxycarbonylamino)acetic acid methyl ester 

Relevant academic research and scientific papers

Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: Synthesis and pharmacology at glutamate receptors

5-Substituted 1-pyrazolol analogues of ibotenic acid have been synthesized and pharmacologically characterized on ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs). The syntheses involved introduction of bromide, alkyls, phenyl and aryla

Synthesis of 5-Substituted 1-Hydroxypyrazoles through Directed Lithiation of 1-(Benzyloxy)pyrazole

1-Hydroxypyrazoles have been converted to 1-(benzyloxy), , , and (silyloxy)pyrazoles. 1-(Benzyloxy)pyrazole was lithiated selectively in the 5-position.Subsequent reaction with electrophiles gives rise to 1-(benzyloxy)pyrazole with carbon, halogen, silicon, sulfur, or tin substituents at the 5-position. 1-(Benzyloxy)pyrazoles could be debenzylated by hydrogen bromide or hydrogenolysis producing 5-substituted 1-hydroxypyrazoles in high overall yield.