166830-76-8

Upstream product

• 166830-74-6 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-((1R,2R)-1,2,3-trihydroxy-propyl)-5,6-dihydro-4H-pyran-2-carboxylic acid 
• 908093-98-1 diazodiphenylmethane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 130525-62-1 5-acetamido-4-amino-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid 

Downstream Products

• 182251-56-5 (4S,5R,6R)-5-Acetylamino-4-amino-6-propylcarbamoyl-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 182251-57-6 (4S,5R,6R)-5-Acetylamino-4-amino-6-(methyl-propyl-carbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 182251-51-0 (2R,3R,4S)-3-Acetylamino-4-(tert-butoxycarbonylamino)-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 
• 182251-53-2 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-propylcarbamoyl-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 182251-54-3 (4S,5R,6R)-5-Acetylamino-4-(tert-butoxycarbonylamino)-6-(methylpropylcarbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 182251-55-4 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-dipropylcarbamoyl-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 182251-52-1 (2R,3R,4S)-3-acetylamino-4-(tert-butoxycarbonylamino)-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluoro-phenyl) ester 
• 1053528-18-9 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-(2-hydroxy-ethylcarbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 1055042-12-0 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-(ethyl-propyl-carbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 1053643-98-3 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-(pyrrolidine-1-carbonyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 1053256-23-7 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-(butyl-propyl-carbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 1053623-53-2 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-cyclohexylcarbamoyl-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 1053644-63-5 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-diallylcarbamoyl-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4h-pyran-6-carboxamides

4-Amino- and 4-guanidino-4ff-pyran-6-carboxamides 4 and 5 related to zanamivir (GG167) are a new class of inhibitors of influenza virus sialidases. Structure-activity studies reveal that, in general, secondary amides are weak inhibitors of both influenza

Synthesis of 6-, 7- and 8-carbon sugar analogues of potent anti-influenza 2,3-didehydro-2,3-dideoxy-N-acetylneuraminic acid derivatives

Analogues of the potent anti-influenza A and B compound, 4-guanidino-Neu5Ac2en, are described in which the stereochemically demanding C-6-glycerol side-chain is truncated.Syntheses of the one- and two-carbon side-chain analogues, of both 4-guanidino- and 4-amino-Neu5Ac2en, are presented, as well as the syntheses of analogues lacking any side-chain.Whilst complete removal of the C-6 side-chain abolishes activity, a stepwise increase in inhibition of influenza neuraminidase and influenza A and B in cell culture with increasing C-6 chain length is observed.The one-carbon, hydroxymethyl derivative retains significant activity to represent a suitable lead in the search for neuraminidase inhibitors of reduced stereochemical demand and synthetic complexity.