182251-53-2Relevant academic research and scientific papers
Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4h-pyran-6-carboxamides
Smith, Paul W.,Sollis, Steven L.,Howes, Peter D.,Cherry, Peter C.,Starkey, Lan D.,Cobley, Kevin N.,Weston, Helen,Scicinski, Jan,Merritt, Andrew,Whittington, Andrew,Wyatt, Paul,Taylor, Neil,Green, Darren,Bethell, Richard,Madar, Safia,Fenton, Robert J.,Morley, Peter J.,Pateman, Tony,Beresford, Alan
, p. 787 - 797 (2007/10/03)
4-Amino- and 4-guanidino-4ff-pyran-6-carboxamides 4 and 5 related to zanamivir (GG167) are a new class of inhibitors of influenza virus sialidases. Structure-activity studies reveal that, in general, secondary amides are weak inhibitors of both influenza
Novel inhibitors of influenza sialidase related to GG167. Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza A virus sialidase
Sollis, Steven L.,Smith, Paul W.,Howes, Peter D.,Cherry, Peter C.,Bethell, Richard C.
, p. 1805 - 1808 (2007/10/03)
N-Propylcarboxamides 1a,b-3a,b have been synthesised from 2,3-didehydro-2,4-dideoxy-4-amino-N-acetylneuraminic acid 4. The tertiary amides 2a,b-3a,b are highly potent but selective inhibitors of influenza A sialidase. The exceptional inhibitory activity of the dipropylamides 3a and 3b against influenza A shows that the 6-dipropylcarboxamide substituent is preferable to the polar glycerol sidechain found in the related sialidase inhibitors GG167 and 4.
