166888-18-2Relevant academic research and scientific papers
Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase
Shearer, Barry G.,Lee, Shuliang,Franzmann, Karl W.,White, Helen A.R.,Sanders, Daniella C.J.,Kiff, Rachel J.,Garvey, Edward P.,Furfine, Eric S.
, p. 1763 - 1768 (2007/10/03)
Conformationally restricted analogues of the endogenous NOS substrate L- arginine and the arginine based NOS inhibitors N(G)-methyl-L-arginine (L- NMA) and Nδ-iminoethyl-L-ornithine (L-NIO) were synthesized for evaluation as inhibitors of human NOS. Incorporation of a phenyl ring into the C4-C5 backbone chain provided 2-aminophenylalanine analogues which retained potent NOS inhibition. Structurally related analogues of 3-aminophenylalanine were significantly weaker inhibitors.
