5454-72-8Relevant academic research and scientific papers
Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids
Frost, John R.,Jacob, Nicholas T.,Papa, Louis J.,Owens, Andrew E.,Fasan, Rudi
, p. 1805 - 1816 (2015/09/01)
A versatile method for orchestrating the formation of side chain-to-tail cyclic peptides from ribosomally derived polypeptide precursors is reported. Upon ribosomal incorporation into intein-containing precursor proteins, designer unnatural amino acids be
MACROCYCLIC PEPTIDOMIMETICS FOR ALPHA-HELIX MIMICRY
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Paragraph 00255, (2015/11/02)
Methods and compositions are provided for generating macrocyclic peptides constrained by side-chain-to-C-terminus non-peptidic tethers for use as functional and structural mimics of α-helical motifs, including in therapeutic applications. These methods can be used to produce libraries of conformationally constrained peptidomimetics to identify compounds with desired activity properties.
