1669-65-4Relevant academic research and scientific papers
Asymmetric dimerization of disubstituted ketenes catalyzed by N-heterocyclic carbenes
Lv, Hui,Zhang, Yan-Rong,Huang, Xue-Liang,Ye, Song
supporting information; experimental part, p. 2715 - 2718 (2009/10/20)
A series of chiral N-heterocyclic carbenes (NHCs), derived from L-pyrogutamic acid, were found to be efficient catalysts for the asymmetric dimerization of alkylarylketenes to give the corresponding α-quaternary β-alkylidenyl-β-lactones in good yields with up to 97% ee. A chiral NHC with a proximal hydroxy group is superior in comparison with the corresponding NHC with its hydroxy group protected.
Oxidative conversion of α,α-disubstituted acetamides to corresponding one-carbon-shorter ketones using hypervalent iodine (λ5) reagents in combination with tetraethylammonium bromide
Bellale, Eknath V.,Bhalerao, Dinesh S.,Akamanchi, Krishnacharya G.
supporting information; experimental part, p. 9473 - 9475 (2009/04/06)
(Chemical Equation Presented) α,α-Disubstituted acetamides undergo oxidative dehomologation to give one-carbon-shorter ketones when reacted with a hypervalent iodine (λ5) reagent in combination with tetraethylammonium bromide (TEAB) in various solvents. In further studies, one such combination of a hypervalent iodine (λ5) reagent, o-iodoxybenzoic acid, and TEAB has been established as a new, mild, efficient, and general method for the transformation.
