16691-00-2

Usage

Uses

Used in Pharmaceutical Development:
CYCLO(-GLU-GLU) is used as a potential drug candidate for its stable cyclic structure, which may contribute to enhanced bioavailability and specificity in targeting various biological pathways. Its small size and unique properties could facilitate the design of new therapeutic agents.
Used in Biochemical Research:
In the field of biochemistry, CYCLO(-GLU-GLU) serves as a research tool to study the behavior and interactions of cyclic peptides within biological systems. Understanding these interactions can provide insights into the development of novel bioactive molecules and the modulation of cellular processes.
Used in Drug Delivery Systems:
CYCLO(-GLU-GLU) may be utilized in the development of drug delivery systems, where its cyclic structure could improve the stability and targeted delivery of therapeutic agents, potentially enhancing their efficacy and reducing side effects.
Used in the Study of Peptide Interactions:
CYCLO(-GLU-GLU) is used as a model compound for investigating the interactions of cyclic peptides with biopolymers and macromolecules, which can aid in the discovery of new peptide-based drugs and the understanding of their mechanisms of action.

Upstream product

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Relevant academic research and scientific papers

Rapidly Recoverable Thixotropic Hydrogels from the Racemate of Chiral OFm Monosubstituted Cyclo(Glu-Glu) Derivatives

Both chiral OFm monosubstituted cyclo(l-Glu-l-Glu) and cyclo(d-Glu-d-Glu) display a robust gelation ability in a variety of organic solvents and water. In contrast to an individual enantiomer, their racemate can form rapidly recoverable thixotropic hydrogels with a remarkably shorter thixotropic recovery time. This unexpected thixotropic behavior is induced by the random arrangement of d- and l-enantiomers in the cell units, leading to the formation of pseudoracemate , noncrystalline self-assemblies in the resulting 3D fibrous network.

Template-assisted photodimerization of: N -unprotected uracil derivatives: Selective formation of the cis - Syn photodimer

A UV light-induced photodimerization of 5-[(imidazol-1-yl)methyl]uracil using glutamate- and aspartate-derived cyclic dipeptides (2,5-diketopiperazines-DKPs) as templates was investigated. Dual salt bridge formation between imidazole side chains and carboxylic acids resulted in the preorganization of the uracil monomers and the preferential formation of the cis-syn photodimer.

Bio-based epoxy resin precursor containing cyclic amide structure, and preparation method and application thereof

The invention discloses a bio-based epoxy resin precursor containing a cyclic amide structure, and also discloses a preparation method and application of the bio-based epoxy resin precursor containingthe cyclic amide structure. The preparation method comp

Five- and six-membered ring opening of pyroglutamic diketopiperazine

A variety of ring-opening reactions of pyroglutamic diketopiperazine at both the five-membered and six-membered rings is described. Mild, basic conditions facilitate nucleophilic attack by amines at the diketopiperazine carbonyls giving pyroglutamides in excellent yield. Reaction with nucleophiles under acidic conditions give bis-glutamate derivatives of 2,5-diketopiperazine (DKP). These reactions provide simple, two-step sequences to pyroglutamides and symmetrical diketopiperazines from commercial pyroglutamic acid with control of product dictated by reaction conditions, catalyst, and nucleophile.

Macromolecular self-assembly of diketopiperazine tetrapeptides

Basic solutions of tetrapeptides derived from L-aspartic acid diketopiperazines are shown to form microcapsules when acidified to pH 2.4. An initial structure-activity study clearly demonstrates that a very delicate balance exists between the tetrapeptide