166964-34-7

Basic information

• Product Name: 5-(4-CHLOROBENZAMIDOMETHYL)THIOPHENE-2-SULPHONYL CHLORIDE
• Synonyms: 5-[[(4-CHLOROBENZOYL)AMINO]METHYL]THIOPHENE-2-SULFONYL CHLORIDE;5-(4-CHLOROBENZAMIDOMETHYL)THIOPHENE-2-SULPHONYL CHLORIDE;5-{[(4-CHLOROBENZOYL)AMINO]METHYL}THIOPH;5-(4-CHLOROBENZAMIDOMETHYL)THIOPHENE-2-SULFONYL CHLORIDE;5-({[1-(4-Chloro-phenyl)-Methanoyl]-aMino}-Methyl)-thiophene-2-sulfonyl chloride;2-{[(4-Chlorobenzoyl)amino]methyl}-5-(chlorosulphonyl)thiophene, 4-Chloro-N-{[5-(chlorosulphonyl)thien-2-yl]methyl}benzamide;5-{[(4-Chlorobenzoyl)amino]methyl}thiophene-2-sulphonyl chloride
• CAS NO: 166964-34-7
• Molecular Formula: C₁₂H₉Cl₂NO₃S₂
• Molecular Weight: 350.24
• Mol File: 166964-34-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 557.1 °C at 760 mmHg
• Flash Point: 290.7 °C
• Appearance: /
• Density: 1.532 g/cm³
• Vapor Pressure: 1.91E-12mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(4-CHLOROBENZAMIDOMETHYL)THIOPHENE-2-SULPHONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-CHLOROBENZAMIDOMETHYL)THIOPHENE-2-SULPHONYL CHLORIDE(166964-34-7)
• EPA Substance Registry System: 5-(4-CHLOROBENZAMIDOMETHYL)THIOPHENE-2-SULPHONYL CHLORIDE(166964-34-7)

Safety Data

• Hazard Codes: C,Xn
• Statements: 22
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 166964-34-7(Hazardous Substances Data)

Usage

General Description

5-(4-chlorobenzamidomethyl)thiophene-2-sulphonyl chloride is a chemical compound used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is a sulfonyl chloride derivative of thiophene, and the presence of the chlorobenzamido group enhances its reactivity and versatility in various chemical reactions. 5-(4-CHLOROBENZAMIDOMETHYL)THIOPHENE-2-SULPHONYL CHLORIDE is commonly employed in the production of sulfonamide drugs and other biologically active molecules. It has also been utilized in the development of new materials and catalysts due to its unique chemical properties. Overall, 5-(4-chlorobenzamidomethyl)thiophene-2-sulphonyl chloride has significant applications in the pharmaceutical and chemical industries, making it a valuable compound in organic synthesis.

InChI:InChI=1/C12H9Cl2NO3S2/c13-9-3-1-8(2-4-9)12(16)15-7-10-5-6-11(19-10)20(14,17)18/h1-6H,7H2,(H,15,16)

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 27757-85-3 2-Aminomethylthiophene 

Downstream Products

• 1161343-04-9 N-((5-(N-(3-(benzo[d]thiazol-2-yl)thiophen-2-yl)sulfamoyl)thiophen-2-yl)methyl)-4-chlorobenzamide 
• 406679-38-7 4-Chloro-N-({5-[(4-oxopiperidin-1-yl)sulfonyl]thien-2-yl}methyl)benzamide 
• 332082-88-9 {5-[(4-chlorobenzoylamino)methyl]thiophene-2-sulfonylamino}acetic acid 

Relevant articles and documents

Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase

Several lines of evidence support the hypothesis that c-Jun N-terminal kinases (JNKs) play a critical role in a wide range of disease states including cell death (apoptosis)-related and inflammatory disorders (epilepsy, brain, heart and renal ischemia, ne