16699-12-0

Basic information

• Product Name: 2-benzenesulfonamidopyrimidine
• Synonyms: 2-benzenesulfonamidopyrimidine;2-(N-(phenylsulfonyl)amino)pyrimidine
• CAS NO: 16699-12-0
• Molecular Formula: C₁₀H₉N₃O₂S
• Molecular Weight: 235.26
• Mol File: 16699-12-0.mol

Chemical Properties

• Melting Point: 229-230 °C
• Boiling Point: 443°Cat760mmHg
• Flash Point: 221.7°C
• Appearance: /
• Density: 1.425g/cm³
• Vapor Pressure: 4.81E-08mmHg at 25°C
• Refractive Index: 1.641
• PKA: 5.99±0.10(Predicted)
• CAS DataBase Reference: 2-benzenesulfonamidopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzenesulfonamidopyrimidine(16699-12-0)
• EPA Substance Registry System: 2-benzenesulfonamidopyrimidine(16699-12-0)

Safety Data

• Hazardous Substances Data: 16699-12-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9N3O2S/c14-16(15,9-5-2-1-3-6-9)13-10-11-7-4-8-12-10/h1-8H,(H,11,12,13)

Upstream product

• 109-12-6 2-aminopyrimidine 
• 98-09-9 benzenesulfonyl chloride 
• 98-10-2 benzenesulfonamide 
• 18213-90-6 2-phenoxypyrimidine 
• 4595-60-2 2-bromopyrimidine 
• 68-35-9 sulfadiazine 

Downstream Products

• 5433-20-5 N-(5-chloro-pyrimidin-2-yl)-benzenesulfonamide 
• 90766-63-5 N-(5-bromo-pyrimidin-2-yl)-benzenesulfonamide 
• 90841-92-2 N-(5-iodo-pyrimidin-2-yl)-benzenesulfonamide 

Relevant articles and documents

Degradation of sulfadiazine antibiotics by water falling film dielectric barrier discharge

A new water falling film dielectric barrier discharge was applied to the degradation of sulfadiazine in the aqueous solution. The various parameters that affect the degradation of sulfadiazine and the proposed evolutionary process were investigated. The results indicated that the inner concentrations of 10 mg/L sulfadiazine can be all removed within 30 min. The optimum pH value was 9.10 and both strong acidic and alkaline solution conditions were not suitable for the degradation. The degradation of sulfadiazine can be enhanced by the addition of hydrogen radical scavengers, but be inhibited by adding hydroxyl radical scavengers. The water falling film dielectric barrier discharge was rather ineffective in mineralization, because of the intermediates were recalcitrant to be degraded. The existence of Fe2+ and CCl 4 in the liquid phase can promote the degradation and mineralization of sulfadiazine. It was found that the degradation of SDZ was enhanced by CCl4 was mainly because of the increase of OH due to the reaction of CCl4 with H that reduce the chances of their recombination with OH. Based on the 8 intermediate products identified by LC-MS, the proposed evolution of the degradation process was investigated.

Copper-catalyzed N-arylation of sulfonamides with aryl bromides under mild conditions

This Letter describes a copper catalyzed sulfonamide coupling reaction with aryl bromides to form N-aryl sulfonamides under mild conditions, including the first examples of Cu-catalyzed sulfonamide coupling at room temperature. The reaction protocol tolerates a broad range of substrates including a variety of primary and secondary sulfonamides and challenging heteroaryl bromides such as 2-bromothiazole.

In vivo and in vitro anti-leishmanial activities of 4-nitro-N-pyrimidinand N-pyrazin-2-ylbenzenesulfonamides, and N2-(4-nitrophenyl)-N 1propylglycinamide

A series of compounds containing the nitrobenzene and sulfonamido moieties were synthesized and their leishmanicidal effect was assessed in vitro against Leishmania infantum promastigotes. Among the compounds evaluated, the p-nitrobenzenesulfonamides 4Aa

Selective monodesulfonylation of N,N-disulfonylarylamines with tetrabutylammonium fluoride

The monodesulfonylation reaction of N,N-bis(methylsulfonyl)-, N,N- bis(phenylsulfonyl)-, and N,N-bis(p-tolylsulfonyl)arylamines easily proceeded using tetrabutylammonium fluoride in tetrahydrofuran under mild conditions to give the corresponding N-monosulfonylarylamines in excellent yields.