167015-84-1

Basic information

• Product Name: 1-BOC-TRYPTAMINE
• Synonyms: 3-AMINOETHYL-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-TRYPTAMINE;3-(2-AMINO-ETHYL)-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;3-(2-Aminoethyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester;tert-butyl3-(2-aMinoethyl)-1H-indole-1-carboxylate;tert-butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate 1H-Indole-1-carboxylic acid, 3-(2-aminoethyl)-, 1,1-dimethylethyl ester
• CAS NO: 167015-84-1
• Molecular Formula: C₁₅H₂₀N₂O₂
• Molecular Weight: 260.33
• Product Categories: pharmacetical
• Mol File: 167015-84-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 395.6°Cat760mmHg
• Flash Point: 193°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 1.82E-06mmHg at 25°C
• Refractive Index: 1.559
• PKA: 9.53±0.10(Predicted)
• CAS DataBase Reference: 1-BOC-TRYPTAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-TRYPTAMINE(167015-84-1)
• EPA Substance Registry System: 1-BOC-TRYPTAMINE(167015-84-1)

Safety Data

• Hazardous Substances Data: 167015-84-1(Hazardous Substances Data)

Usage

General Description

1-BOC-TRYPTAMINE, also known as N-tert-butyloxycarbonyltryptamine, is a derivative of tryptamine that has a chemical formula of C15H21N3O2. It is often used as a precursor in the synthesis of various compounds, including pharmaceuticals and research chemicals. The BOC protecting group serves to block the reactivity of the amine functional group, allowing for selective reactions at other sites in the molecule. 1-BOC-TRYPTAMINE is commonly utilized in the field of organic chemistry and is available for purchase from various chemical suppliers for research and development purposes.

InChI:InChI=1/C15H20N2O2/c1-15(2,3)19-14(18)17-10-11(8-9-16)12-6-4-5-7-13(12)17/h4-7,10H,8-9,16H2,1-3H3

Upstream product

• 61-54-1 tryptamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1123495-86-2 tert-butyl 3-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-1H-indole-1-carboxylate 
• 319-76-6 N-(2-(1H-indol-3-yl)ethyl)-2,2,2-trifluoroacetamide 
• 32539-42-7 (2-(1H-indol-3-yl)ethyl)carbamic acid phenyl ester 
• 792909-25-2 3-(2-phenoxycarbonylamino-ethyl)-indole-1-carboxylic acid tert-butyl ester 
• 221357-19-3 tert-butyl 3-(2-(2,2,2-trifluoroacetamido)ethyl)-1H-indole-1-carboxylate 

Downstream Products

• 932743-60-7 C₂₃H₃₀N₂O₄ 
• 10252-12-7 indoloquinolizidine 
• 1444254-70-9 (1S,12bR)-4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]-quinolizin-1-yl phenyl carbonate 

Relevant articles and documents

Combined Approach of Backbone Amide Linking and On-Resin N-Methylation for the Synthesis of Bioactive and Metabolically Stable Peptides

Rhabdopeptides are a large class of nonribosomal peptides from the bacteria Xenorhabdus and Photorhabdus with low micromolar activity against different protozoa, which are the causative agents of several tropical diseases. The development of a facile and flexible synthesis combining backbone amide linking with on-resin peralkylation for the synthesis of permethylated rhabdopeptides is described. This strategy allows the fast generation of permethylated naturally occurring and artificial rhabdopeptides for a structure-activity study. Furthermore, in vitro experiments revealed their superior properties regarding their stability and passive membrane diffusion.

INHIBITORS FOR PROLIFERATING CELL NUCLEAR ANTIGEN AND USES

The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure.

Toward general access to the Aspidosperma-type terpenoid indole alkaloids: Synthesis of the key 3,3-disubstituted piperidones through enantioselective intramolecular Heck-type reaction of chloroformamides

An enantioselective intramolecular Heck-type reaction of chloroformamides has been developed for the synthesis of 3,3-disubstituted piperidones. The desired piperidone was formed in the presence of a palladium catalyst, an optically active phosphoramidite ligand, K3PO4 and Ag 3PO4. The obtained piperidone was converted to epieburnamonine.