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2,2,2-Trifluoro-N-(2-indol-3-ylethyl)ethanamide is a chemical compound with the molecular formula C11H10F3N2O. It is a derivative of ethanamide, featuring a trifluoromethyl group (CF3) and an indole-3-ylethyl group attached to the nitrogen atom. 2,2,2-TRIFLUORO-N-(2-INDOL-3-YLETHYL)ETHANAMIDE is known for its potential applications in medicinal chemistry, particularly as a building block for the synthesis of various pharmaceuticals and bioactive molecules. The presence of the indole ring, a common structural motif in many natural products and drugs, suggests that 2,2,2-TRIFLUORO-N-(2-INDOL-3-YLETHYL)ETHANAMIDE may have interesting biological properties. Its synthesis and use in the development of new drugs are areas of ongoing research in the field of organic chemistry and drug discovery.

319-76-6

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319-76-6 Usage

Derived from

Synthetic derivative of indole (heterocyclic aromatic organic compound)

Application in research

Selective antagonist for the serotonin 5-HT3 receptor in biochemistry and molecular biology

Potential therapeutic uses

Treatment of diseases such as schizophrenia, depression, and as an analgesic

Receptor interaction

Potent and selective inhibitor of the serotonin receptor

Importance

Valuable tool for studying the role of serotonin in various physiological and pathological conditions

Check Digit Verification of cas no

The CAS Registry Mumber 319-76-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 319-76:
(5*3)+(4*1)+(3*9)+(2*7)+(1*6)=66
66 % 10 = 6
So 319-76-6 is a valid CAS Registry Number.

319-76-6Relevant academic research and scientific papers

Nucleophilic substitution reactions on indole nucleus: Formation of (3a,8a-cis)-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indoles having a substituent at the 3a-position

Yamada, Fumio,Goto, Aya,Hasegawa, Masakazu,Kobayashi, Kensuke,Somei, Masanori

, p. 844 - 861 (2017/07/28)

Various nucleophiles, such as indole, 1,2,3-trimethoxybenzene, anisole, phenol, and pyrrole, reacted with 1-hydroxy-Nb-trifluoroacetyltryptamine under the presence of mesyl chloride to give novel series of (3a,8acis)- 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles having a substituent at the 3aposition. Their structures and by-products were strictly determined.

Nucleophilic substitution reaction on the nitrogen of indole nucleus: A novel synthesis of 1-aryltryptamines

Hayashi, Toshikatsu,Peng, Wu,Nakai, Yu Ya,Yamada, Koji,Somei, Masanori

, p. 421 - 424 (2007/10/03)

1-Hydroxytryptamine derivatives undergo nucleophilic substitution reaction on the indole nitrogen (Na) as a general reaction by the treatment with acid, providing a novel synthetic method for 1-aryltryptamines. Depending on the structures of nucleophiles,

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