167024-67-1

Basic information

• Product Name: 2-aMino-2-(4-(trifluoroMethyl)phenyl)acetonitrile
• Synonyms: 2-aMino-2-(4-(trifluoroMethyl)phenyl)acetonitrile
• CAS NO: 167024-67-1
• Molecular Formula: C9H7F3N2
• Molecular Weight: 200.1604896
• Mol File: 167024-67-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-aMino-2-(4-(trifluoroMethyl)phenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-2-(4-(trifluoroMethyl)phenyl)acetonitrile(167024-67-1)
• EPA Substance Registry System: 2-aMino-2-(4-(trifluoroMethyl)phenyl)acetonitrile(167024-67-1)

Safety Data

• Hazardous Substances Data: 167024-67-1(Hazardous Substances Data)

Usage

General Description

2-amino-2-(4-(trifluoromethyl)phenyl)acetonitrile is a chemical compound with the molecular formula C9H8F3N3. It is also known by the trade name Mexiletine, and is used as an antiarrhythmic medication to treat irregular heartbeats. It works by stabilizing the heart's electrical activity and preventing abnormal rhythms from occurring. Mexiletine belongs to the class of drugs known as local anesthetics, and it acts by blocking sodium channels in the heart muscle. This helps to regulate the heartbeat and restore normal rhythm in patients with certain heart conditions. It is typically administered orally in the form of a capsule or tablet, and is available by prescription only.

Upstream product

• 168013-75-0 (+/-)-2-hydroxy-2-(4-trifluoromethylphenyl)acetonitrile 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 773837-37-9 sodium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 3300-51-4 p-Trifluoromethylbenzylamine 

Relevant articles and documents

Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia

α-Aminonitrile was an important building block in natural products and key intermedia in organic chemistry. Herein, the direct amination of cyanohydrins with the partner of ammonia to synthesis N-unprotected α-aminonitriles is developed. The reaction proceeds via titanium-catalyzed cyano-borrowing reaction, which features high atom economy and simple operation. A broad range of ketone or aldehyde cyanohydrins was tolerated with ammonia, and the N-unprotected α-aminonitriles were synthesis with moderate to high yields under mild reaction conditions.

Gold-catalyzed [3+2]-annulations of α-aryl diazonitriles with ynamides and allenamides to yield 1-amino-1H-indenes

Gold-catalyzed [3+2]-annulations of α-aryl diazonitriles with ynamides and allenamides yield 1-amino-1H-indenes in two distinct pathways; the success of these annulations relies on the high electrophilicity of α-cyano arylgold carbenes to activate an ionic pathway.