167032-11-3

Upstream product

• 4301-07-9 β-Chlor-pivalophenon 

Downstream Products

• 133797-53-2 (R)-(-)-3-methoxy-2,2-dimethyl-3-phenylpropanol 
• 133797-53-2 (S)-(+)-3-methoxy-2,2-dimethyl-3-phenylpropanol 

Relevant academic research and scientific papers

Phase-transfer synthesis of optically pure oxetanes obtained from 1,2,2-trisubstituted 1,3-propanediols

Treatment of the 3-monomethanesulfonates of 1,2,2-trisubstituted 1,3-propanediols under phase-transfer conditions affords 2-aryl (or alkyl)-3,3-dialkyloxetanes. Twelve oxetanes have been obtained by this method; three of these oxetanes have been obtained enantiomerically pure as both enantiomers starting from the appropriate enantiomerically pure 1,3-diols. In these reactions the chiral center does not undergo inversion and the oxetanes have the same absolute configuration as the starting 1,3-diols.

Asymmetric Synthesis of 2-Aryl Substituted Oxetanes by Enantioselective Reduction of β-Halogenoketones using Lithium Borohydride modified with N,N'-Dibenzoylcystine

Optically active 2-aryl substituted oxetanes are synthesised in high enantiomeric excesses (up to 89percent e.e.) via enantioselective reduction of β-halogenoketones with lithium borohydride using (R,R')-N,N'-dibenzoylcystine and t-butyl alcohols as ligands.