1671-48-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-5-(methylsulfonyl)aniline is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
As a potential fungicide and pesticide, 2-Methyl-5-(methylsulfonyl)aniline is utilized in the agricultural sector to protect crops from fungal infections and pests, thereby enhancing crop yield and quality.
Used in Dye and Pigment Manufacturing:
2-Methyl-5-(methylsulfonyl)aniline is employed as a key component in the production of dyes and pigments, playing a crucial role in the coloration of various materials and products.

Upstream product

• 1671-49-4 1‐methyl‐4‐(methylsulfonyl)‐2‐nitrobenzene 
• 1671-40-5 5-Methylsulfonyl-2-methyl-acetanilid 
• 3185-99-7 Methyl p-tolyl sulfone 
• 120-66-1 N-(2-methylphenyl)acetamide 

Downstream Products

• 100959-90-8 2-iodo-1-methyl-4-(methylsulfonyl)benzene 
• 347196-42-3 2-Chloro-N-(2-methyl-5-methanesulphonylphenyl)acetamide 
• 1671-49-4 1‐methyl‐4‐(methylsulfonyl)‐2‐nitrobenzene 

Relevant academic research and scientific papers

Aniline pyrimidines, its preparation method and medical use (by machine translation)

The invention relates to: an aniline pyrimidine compound represented as the formula (I), a medicinal salt thereof, a prodrug thereof, and a hydrate or solvate thereof and also relates to: the preparation method of the compound, a medicine composition comp

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases

New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with Ki 50 100 nM; PGD2-induced eosinophil shape change). Additional optimization of the PK characteristics led to the identification of several compounds suitable for in vivo testing. Of these, 19k and 19s were tested in two different pharmacological models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg).

PHENOXY ACETIC ACID DERIVATIVES

The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.