167107-72-4Relevant articles and documents
One-pot synthesis of 3,5-disubstituted isoxazoles from propargylic alcohols through propargylic N-hydroxylamines
Raji Reddy, Chada,Vijaykumar, Jonnalagadda,Jithender, Enukonda,Reddy, Gangireddy Pavan Kumar,Gree, Rene
, p. 5767 - 5773 (2012/11/07)
An efficient approach has been described for the synthesis of 3,5-disubstituted isoxazoles from propargylic alcohols. The strategy involves a one-pot p-TSA-catalyzed N-propargylation of protected hydroxylamines followed by a TBAF-mediated detosylative 5-endo-dig cyclization. The method was successfully used for the synthesis of various 3,5-disubstituted isoxazoles.