167155-75-1Relevant academic research and scientific papers
Stereochemistry of C-6 nucleophilic displacements on 1,1- difluorocyclopropyldibenzosuberanyl substrates. An improved synthesis of multidrug resistance modulator LY335979 trihydrochloride
Barnett, Charles J.,Huff, Bret,Kobierski, Michael E.,Letourneau, Michael,Wilson, Thomas M.
, p. 7653 - 7660 (2004)
Studies of the displacement chemistry of 1,1- difluorocyclopropyldibenzosuberanyl alcohol 4 and its activated bromide derivative 6 have led to an improved approach to anti-2, a key precursor to LY335979 3HCl (1). Bromination of either syn-4 or anti-4 gave
