167156-15-2

Upstream product

• 98-62-4 4-aminobenzenesulfonyl fluoride 
• 243869-56-9 R/S-3,3,3-trifluoro-2-hydroxy-2-methylproanoyl chloride 
• 374-35-6 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 

Relevant academic research and scientific papers

4-Sulfonamidoanilide tertiary carbinols: A novel series of potassium channel openers

Sulfonamides are viable replacements for the phenylsulfonyl and benzoyl moieties initially described for the anilide tertiary carbinol series of K(ATP) potassium channel openers. The SAR of this new series and the synthetic chemistry employed to generate its members are described.

Aminosulfonylphenyl compounds for treating urinary incontinence

Compounds of formula I STR1 wherein R 1, R 2, R 3, R 4, R 5 and A-B have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinery incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.