167172-14-7

Usage

General Description

1H-Indole, 1-(phenylsulfonyl)-3-(2-propenyl)- is a chemical compound with the molecular formula C19H17NO2S. It is a derivative of indole and contains a phenylsulfonyl group and a propenyl group. 1H-Indole, 1-(phenylsulfonyl)-3-(2-propenyl)- is a potential inhibitor of the aryl hydrocarbon receptor and has been studied for its potential use in cancer therapy. It exhibits anti-proliferative and anti-inflammatory properties and has been investigated for its role in the regulation of various cellular processes. Additionally, it has been studied for its potential use in the treatment of neurodegenerative diseases and as a tool for chemical biology research.

Upstream product

• 80360-14-1 3-iodo-1-phenylsulfonyl-1H-indole 
• 106-95-6 allyl bromide 

Downstream Products

• 752212-08-1 3-allyl-1-benzenesulfonyl-1H-indole-2-carbaldehyde 
• 1374399-74-2 1-(benzenesulfonyl)-3-methyl-2-[(R)-2-methyl-4-phenyl-1,3-oxazolidin-2-yl]indole 
• 143774-63-4 2-acetyl-3-methyl-1-(phenylsulfonyl)indole 
• 1374399-65-1 2-acetyl-1-(phenylsulfonyl)-3-indoleacetic acid 
• 752212-09-2 1-(3-allyl-1-benzenesulfonyl-1H-indol-2-yl)-but-3-en-1-ol 

Relevant academic research and scientific papers

Preparation of highly functionalized heterocyclic zinc organometallics via a Li(acac)-catalysis of the I/Zn-exchange reaction

The reaction of i-Pr2Zn in the presence of catalytic amount of Li(acac) in NMP with various functionalized heterocyclic iodides provides new polyfunctional diheteroarylzincs, which undergo smooth Negishi cross-coupling reactions and CuCN-2LiCl-

Generation of arylzinc reagents through an iodine-zinc exchange reaction promoted by a non-metallic organic superbase

Functionalized aryl and heteroaryl zinc reagents were prepared from aryl iodides and diethylzinc through t-Bu-P4 base-promoted iodine-zinc exchange reactions. The scope and limitations of this protocol, and several applications for the synthesis of oligoaryls and fused aromatics, are presented.

Preparation and reactions of lithium indolyl(dimethyl)zincates

Lithium indol-3-yl(dimethyl)zincates, prepared by halogen-zinc exchange of 3-iodo-1-phenylsulfonylindoles with lithium trimethylzincate, reacted with benzaldehyde to give the corresponding alcohols.