1672-91-9Relevant academic research and scientific papers
Synthesis method of sulfachloropyrazine sodium
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Paragraph 0033-0036; 0038-0039; 0041-0055, (2020/06/17)
The invention relates to a synthesis method of sulfachloropyrazine sodium. The preparation method is characterized by comprising the following steps of: S1, sequentially adding 4-aminobenzene-1-sulfonyl chloride, 2-amino-6-chloropyrazine and an organic solvent into a reaction kettle, then slowly adding an acid-binding agent into the reaction kettle within 2-4h, and performing stirring for 12-20h under a pressure of 0.8-1.3MPa and a temperature of 30-50DEG C to obtain a first mixed solution; adjusting the pH value to 4.5-5.3 with hydrochloric acid, and performing filtering and washing to obtainsulfachloropyrazine; and S3, putting the sulfachloropyrazine prepared in S2 into a sodium hydroxide solution, performing heating for dissolving, conducting cooling for crystallization, and performingfiltering to obtain sulfachloropyrazine sodium. The synthesis method of sulfachloropyrazine sodium disclosed by the invention is simple and practicable, the raw material sources are rich, the price is low, the preparation efficiency, yield and product purity are high, the preparation process is green and environment-friendly, and good combination of economic benefits, social benefits and ecological benefits is effectively realized.
