24939-24-0

Basic information

• Product Name: 4-Aminobenzene-1-sulfonyl chloride
• Synonyms: 4-Aminobenzene-1-sulfonyl chloride;Benzenesulfonyl chloride, 4-aMino-;p-Aminobenzenesulfonyl chloride;Benzenesulfonylchloride, 4-amino- HCL Salt
• CAS NO: 24939-24-0
• Molecular Formula: C₆H₆ClNO₂S
• Molecular Weight: 191.63534
• Mol File: 24939-24-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 330.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.492
• PKA: 0.84±0.10(Predicted)
• CAS DataBase Reference: 4-Aminobenzene-1-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Aminobenzene-1-sulfonyl chloride(24939-24-0)
• EPA Substance Registry System: 4-Aminobenzene-1-sulfonyl chloride(24939-24-0)

Safety Data

• Hazardous Substances Data: 24939-24-0(Hazardous Substances Data)

Usage

General Description

4-Aminobenzene-1-sulfonyl chloride, also known as p-toluenesulfonyl chloride, is an organic compound with the chemical formula C7H7NO2S. This white crystalline solid is commonly used as a reagent in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is a versatile building block in organic chemistry, often utilized in the creation of sulfonamides, sulfonate esters, and sulfonamide-based inhibitors. Additionally, it is utilized in the synthesis of polymers and as a coupling reagent in peptide synthesis. Due to its reactivity and versatility, 4-aminobenzene-1-sulfonyl chloride is a valuable tool in the development of various chemical compounds and materials. However, it is important to handle this compound with caution, as it is corrosive and can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 515-74-2 sodium sulfanilate 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 25111-75-5 3-(4-Amino-benzolsulfonylamino)-propionsaeure-nitril 
• 68597-57-9 4-amino-N-[4-(3-chloro-2-methoxy-phenyl)-5-methyl-thiazol-2-yl]-benzenesulfonamide 
• 68597-58-0 4-amino-N-[4-(5-chloro-2-methoxy-phenyl)-5-methyl-thiazol-2-yl]-benzenesulfonamide 
• 127-69-5 sulfisoxazole 
• 93987-20-3 sulfanilic acid-(3-phenyl-isoxazol-5-ylamide) 
• 98-62-4 4-aminobenzenesulfonyl fluoride 
• 5616-30-8 2-(4-aminobenzenesulfonylamino)ethanoic acid 
• 96197-04-5 7-<4-Amino-benzosulfonylamino>-heptansaeure 
• 93760-87-3 4-amino-N-(5-cyclohexyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonamide 
• 53855-94-0 4-Amino-N-[2-(2-hydroxy-3-phenoxy-propylamino)-ethyl]-benzenesulfonamide 
• 46204-38-0 4-Chlorsulfonyl-N-sulfinylanilin 
• 97158-69-5 1,2-Bis-(4-amino-benzolsulfonamidooxy)-ethan 
• 96749-68-7 4-amino-N-(4-isobutyl-thiazol-2-yl)-benzenesulfonamide 
• 5450-86-2 para-aminophenylsulfonyl hydrazide 

Relevant articles and documents

The synthesis of sulfonated 4: H -3,1-benzoxazines via an electro-chemical radical cascade cyclization

A new route for the synthesis of sulfonated 4H-3,1-benzoxazines has been accomplished by electrochemical radical cascade cyclizations of styrenyl amides with sulfonylhydrazines. This process demonstrates a wide substrate scope with diverse functional group compatibility under metal- and external oxidant-free conditions at ambient temperature.

High Performance and Active Sites of a Ceria-Supported Palladium Catalyst for Solvent-Free Chemoselective Hydrogenation of Nitroarenes

Cerium oxide-supported palladium catalysts (Pd/CeO2) prepared by a simple impregnation method exhibit exciting catalytic activity and high chemoselectivity for the solvent-free hydrogenation of a variety of substituted nitroarenes including the reducible functional groups to the corresponding aromatic amines under mild reaction conditions. Taking nitrobenzene as an example, the Pd/CeO2 catalyst can afford aniline yields of >99 % with turnover frequencies as high as 11 411 h?1 and 69 824 h?1 at 40 °C and 100 °C, respectively. Pd2+ ion species exist as isolated single atoms with ?Pd2+?O2??Ce4+? linkages on the surface of PdxCe1?xO2?σ solid solution and are found to be active sites for the selective hydrogenation of nitroarenes in the absence of solvent. The superior catalytic performance can be attributed to the cooperative effect between Pd2+ ions and unique surface sites of CeO2. A possible mechanism is proposed for the hydrogenation of nitroarenes with H2 over the Pd/CeO2. The Pd/CeO2 catalyst can be recovered easily and reused for at least seven recycling reactions without loss of catalytic properties.