16723-54-9

Basic information

• Product Name: 8-Methyl-3,4-dihydro-4-oxo-2H-1-benzothiopyran 1,1-dioxide
• Synonyms: 8-Methyl-3,4-dihydro-4-oxo-2H-1-benzothiopyran 1,1-dioxide
• CAS NO: 16723-54-9
• Molecular Formula: C10H10O3S
• Molecular Weight: 210.25
• Mol File: 16723-54-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Methyl-3,4-dihydro-4-oxo-2H-1-benzothiopyran 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methyl-3,4-dihydro-4-oxo-2H-1-benzothiopyran 1,1-dioxide(16723-54-9)
• EPA Substance Registry System: 8-Methyl-3,4-dihydro-4-oxo-2H-1-benzothiopyran 1,1-dioxide(16723-54-9)

Safety Data

• Hazardous Substances Data: 16723-54-9(Hazardous Substances Data)

Upstream product

• 137-06-4 2-thiocresol 
• 59280-48-7 3-(2-methylphenylthio)propionic acid 
• 29373-02-2 8-methyl-3,4-dihydro-1-benzothiopyran-4-one 

Relevant articles and documents

Synthesis and anticancer activities of thiosemicarbazones derivatives of thiochromanones and related scaffolds

A series of novel thiosemicarbazone analogs (4a–t, 6a–j) were synthesized and evaluated for their cytotoxic activities. The obtained results showed that thiochromanone-based thiosemicarbazones substituted primarily at the C-8 position exhibited higher cytotoxicity than the corresponding 1,1-dioxo-thiochromanone-, benzothiazepine-, and 1,1-dioxo-benzothiazepine-based analogs. Significantly, compound 4c (8-fluoro thiochromanone thiosemicarbazone) was found to be the most active and exhibited potent cytotoxicity against the MCF-7, SK-mel-2, and DU145 cancer cell lines, with IC50 values of 0.42, 0.58, and 0.43 μM, respectively. In addition, the mechanism of compound 4c induced MCF-7 cell apoptosis was preliminarily investigated through cell cycle, Annexin V-FITC/PI staining, and ROS assays, indicating that compound 4c may exert its anticancer property through ROS-mediated apoptosis.