137-06-4

Basic information

• Product Name: 2-Methylbenzenethiol
• Synonyms: 2-mercapto-toluen;2-Methybenzenethiol;2-methyl-benzenethio;2-methylmercaptobenzene;2-methylphenylmercaptan;2-Toluenethiol;Benzenethiol,2-methyl-;o-Mercaptotoluene
• CAS NO: 137-06-4
• Molecular Formula: C₇H₈S
• Molecular Weight: 124.2
• EINECS: 205-276-8
• Product Categories: Phenol&Thiophenol&Mercaptan;thiol Flavor
• Mol File: 137-06-4.mol
• Article Data: 26

Chemical Properties

• Melting Point: 10-12 °C(lit.)
• Boiling Point: 195 °C(lit.)
• Flash Point: 147 °F
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 1.054 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.601mmHg at 25°C
• Refractive Index: n20/D 1.578(lit.)
• Storage Temp.: Store below +30°C.
• PKA: pK1:6.64 (25°C)
• Explosive Limit: 1.1%(V)
• Water Solubility: insoluble
• Sensitive: Stench
• Merck: 14,9325
• BRN: 774068
• CAS DataBase Reference: 2-Methylbenzenethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylbenzenethiol(137-06-4)
• EPA Substance Registry System: 2-Methylbenzenethiol(137-06-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 37/38-41-36/37/38-20/21/22
• Safety Statements: 26-39-36/37/39-23
• RIDADR: 2810
• WGK Germany: 3
• RTECS: XT8750000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 137-06-4(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 137-06-4 differently. You can refer to the following data:
1. CLEAR COLOURLESS TO SLIGHTY YELLOW-BROWN LIQUID
2. 2-Methylthiophenol has a disagreeable odor. This compound is erroneously called o-toluenethiol.

Occurrence

Reported found in coffee

Uses

2-Thiocresol performs a fungicidal and inhibitory activity against Histoplasma capsulatum. Reagent for molecular modeling and preparation of 4-hydroxy-5,6-dihydropyrones as inhibitors of HIV protease.

Taste threshold values

Taste characteristics at 4 ppm: meaty, onion, garlic, chemical and metallic.

InChI:InChI=1/C7H8S/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3/p-1

Synthetic route

ortho-methylphenyl iodide (615-37-2) → 2-thiocresol (137-06-4)

Conditions	Yield
With copper(ll) sulfate pentahydrate; ethane-1,2-dithiol; potassium hydroxide In water; dimethyl sulfoxide at 90℃; for 20h; Inert atmosphere;	96%
Stage #1: ortho-methylphenyl iodide With copper(l) iodide; potassium carbonate; sulfur In N,N-dimethyl-formamide at 90℃; for 12h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In N,N-dimethyl-formamide at 40℃; Inert atmosphere; Cooling with ice;	90%
With sodiumsulfide nonahydrate; copper; ethane-1,2-dithiol In dimethyl sulfoxide at 100℃; for 20h; Inert atmosphere; Green chemistry;	88%
With copper(l) iodide; thiourea; L-proline; sodium t-butanolate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;	86%

2-methylphenyl bromide (95-46-5) → 2-thiocresol (137-06-4)

Conditions	Yield
With hydrogen sulfide at 360℃; Reagent/catalyst;	98.5%
Stage #1: 2-methylphenyl bromide With water; caesium carbonate; sodium thiosulfate; bis(dibenzylideneacetone)-palladium(0); XPhos In toluene; tert-butyl alcohol at 80℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride; zinc In water for 1h; Cooling with ice;	75%
With sulfur; magnesium 1.) ether; Multistep reaction;

Dimethyldisulphide (624-92-0) + phenol (108-95-2) → 2-thiocresol (137-06-4)

Conditions	Yield
With hydrogenchloride; aluminium chloride In diethyl ether; toluene; Petroleum ether

bis(2-methylphenyl)disulfide (4032-80-8) → 2-thiocresol (137-06-4)

Conditions	Yield
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran at 0 - 35℃;	96%
With sodium tetrahydroborate; zirconium(IV) chloride In tetrahydrofuran at 35℃; for 0.166667h; Reduction;	95%

Dimethyldisulphide (624-92-0) + phenol (108-95-2) → para-thiocresol (106-45-6) + 2-thiocresol (137-06-4)

Conditions	Yield
With iron(III) chloride In Petroleum ether

methyl o-tolyl sulfide (14092-00-3) → 2-thiocresol (137-06-4)

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; diethylamine In xylene for 6h; Heating;	85%

toluene (108-88-3) → para-thiocresol (106-45-6) + 2-thiocresol (137-06-4)

Conditions	Yield
Stage #1: toluene With trifluoromethylsulfonic anhydride; (MeO2CH2CH2)2SO In dichloromethane at -35 - 20℃; Stage #2: With triethylamine In tetrahydrofuran at 20℃; for 12h; Stage #3: With potassium tert-butylate In tetrahydrofuran at -78℃; for 0.166667h; Title compound not separated from byproducts;

S-o-tolyl dimethylcarbamothioate (7305-14-8) → 2-thiocresol (137-06-4)

Conditions	Yield
With potassium hydroxide In tetrahydrofuran; methanol for 3h; Ambient temperature;

O‐(o‐tolyl) dimethylcarbamothioate (10345-39-8) → 2-thiocresol (137-06-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: 2 h / 210 °C 2: KOH / tetrahydrofuran; methanol / 3 h / Ambient temperature View Scheme

ortho-cresol (95-48-7) + colloid/al platinum → 2-thiocresol (137-06-4)

Conditions	Yield
Multi-step reaction with 3 steps 1: 1,4-diazabicyclo<2.2.2>octane (dabco) / dimethylformamide / 1.5 h / 60 - 70 °C 2: 2 h / 210 °C 3: KOH / tetrahydrofuran; methanol / 3 h / Ambient temperature View Scheme

2-methylchlorobenzene (95-49-8) → 2-thiocresol (137-06-4)

Conditions	Yield
With sodium hydroxide; n-butanethiol 1) N-methyl-2-pyrrolidone, removal of water by toluene reflux, 2) reflux (ca. 186 deg C), 20 h; Yield given. Multistep reaction;
With pumice stone; hydrogen sulfide at 700℃;
With pumice stone; hydrogen sulfide; thorium dioxide at 700℃;

Benzo[b]thiophene (95-15-8) → 2-thiocresol (137-06-4)

Conditions	Yield
With potassium hydroxide at 300 - 310℃; im Autoklaven;

ortho-methylphenyl iodide (615-37-2) + thiourea (17356-08-0) → 2-thiocresol (137-06-4)

Conditions	Yield
With sodium hydroxide; bis(triethylphosphine)nickel(II) chloride; sodium cyanoborohydride 1.) DMF, 60 deg C, 10 h, 2.) water, room temperature; Yield given. Multistep reaction;

2,2,4,4-tetrachloro-2,4-dihydro-1,3-benzodithiin (87641-74-5) → 2-thiocresol (137-06-4)

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 7h; Heating; Title compound not separated from byproducts;

dithiocarbonic acid O-ethyl ester-S-o-tolyl ester (24022-34-2) → 2-thiocresol (137-06-4)

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

(3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-9-methyl-6-methylene-3-o-tolylsulfanylmethyl-octahydro-azuleno[4,5-b]furan-2,8-dione (248584-39-6) → grosheimin (22489-66-3) + 2-thiocresol (137-06-4)

Conditions	Yield
With phosphate buffer In methanol at 37℃; pH=7.4; Kinetics; Hydrolysis;

Toluene-2-sulfonyl chloride (133-59-5) → 2-thiocresol (137-06-4)

Conditions	Yield
With sulfuric acid elektrochemische Reduktion;
With hydrogenchloride; iron

[(2-Methylphenyl)sulfanyl]acetic acid (18619-15-3) → 2-thiocresol (137-06-4)

Conditions	Yield
With perchloric acid; pyridinium chlorochromate In water; acetic acid at 24.85 - 44.85℃; Kinetics; Oxidation;

ortho-tolylmagnesium bromide (932-31-0) → 2-thiocresol (137-06-4)

Conditions	Yield
With diethyl ether; sulfur Zersetzung des Reaktionsproduktes mit angesaeuertem Wasser;

2-methylbenzene diazonium (17333-74-3) → di-o-tolyl sulfide (4537-05-7) + 2-thiocresol (137-06-4)

Conditions	Yield
With sodium sulfide
With sodium sulfide

4-bromo-toluene-2-sulfonic acid (56919-17-6) → 2-thiocresol (137-06-4)

Conditions	Yield
With hydrogenchloride; tin Behandeln des Reaktionsprodukts in Alkohol mit Natriumamalgam;

o-toluidine (95-53-4) → 2-thiocresol (137-06-4)

Conditions	Yield
With hydrogenchloride; sodium nitrite Eintragen des Reaktionsgemisches in wss. Natriumpolysulfid und Erhitzen des danach erhaltenen Reaktionsprodukts mit wss. NaOH;

2-Methyl-benzenethiol → 2-thiocresol (137-06-4)

Conditions	Yield
With triethylamine In various solvent(s) Kinetics; Reduction;

potassium ethyl xanthogenate (140-89-6) + o-toluene-diazonium chloride (2028-34-4) → 2-thiocresol (137-06-4)

Conditions	Yield
Erwaermen auf ca. 70grad und Verseifung mit alkoh. Kalilauge;

[(2-Methylphenyl)sulfanyl]acetic acid (18619-15-3) → Glyoxilic acid (298-12-4) + 2-thiocresol (137-06-4)

Conditions	Yield
With perchloric acid; sodium perborate; acetic acid at 24.9℃; Rate constant; Thermodynamic data; Mechanism; var. temp., ΔH(excit.), ΔS(excit.);

1-chloro-2-(chloromethyl)benzene (611-19-8) → 2-methylchlorobenzene (95-49-8) + (E)-2,2'-dichlorostilbene (25144-38-1) + 1,2-bis(2-chlorophenyl)ethane (6639-40-3) + 1,1-di(2-chlorophenyl)ethylene (97063-37-1) + 2-thiocresol (137-06-4)

Conditions	Yield
With hydrogen sulfide at 560℃; Product distribution; thermolysis in stream of hydrogen sulfide;

2-ethoxy-S-allylthiophenol (102968-96-7) → styrene (292638-84-7) + 1-benzofurane (271-89-6) + acetophenone (98-86-2) + 2-thiocresol (137-06-4) + phenol (108-95-2)

Conditions	Yield
at 750℃; under 0.001 - 0.005 Torr; for 0.333333h; Mechanism; pyrolysis of o-substituted N-, O-, and S-allyl compounds;

(Dimethylamino-o-tolylsulfanyl-methylene)-dimethyl-ammonium; iodide → tetramethylurea (632-22-4) + 2-thiocresol (137-06-4)

Conditions	Yield
at 20℃; Rate constant; pH=11;

Benzo[b]thiophene (95-15-8) + potassium hydroxide → 2-thiocresol (137-06-4)

Conditions	Yield
at 300 - 310℃; im Autoklaven;

2-thiocresol (137-06-4) → bis(2-methylphenyl)disulfide (4032-80-8)

Conditions	Yield
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In chloroform at 20℃; for 0.0166667h;	100%
With aluminum oxide; sodium iodate In hexane at 20℃; for 0.5h;	99%
With N,N,N,N,-tetramethylethylenediamine; eosin y In ethanol for 2h; Irradiation;	99%

2-thiocresol (137-06-4) + methyl iodide (74-88-4) → methyl o-tolyl sulfide (14092-00-3)

Conditions	Yield
With potassium carbonate In acetone at 25℃; for 17h;	100%
With sodium hydride In N,N-dimethyl-formamide 1.) 0 deg C, 15 min, 2.) room temperature, 45 min;	97%
With potassium carbonate In acetone at 20℃; for 18h;	95%

4-iodobenzoic acid (619-58-9) + 2-thiocresol (137-06-4) → 4-[(2-methylphenyl)thio]benzamide

Conditions

Yield

Stage #1: 4-iodobenzoic acid With SPPSLRAM SynPhase Lanterns(R); N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 45℃; for 15h; Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane

100%

4-iodobenzoic acid (619-58-9) + 2-thiocresol (137-06-4) → 4-[(2-methylphenyl)thio]benzoic acid

Conditions	Yield
Stage #1: 4-iodobenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane	100%

3-iodo-4-toluic acid (82998-57-0) + 2-thiocresol (137-06-4) → 4-methyl-3-[(2-methylphenyl)thio]benzoic acid

Conditions	Yield
Stage #1: 3-iodo-4-toluic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane	100%

4-iodo-3-methylbenzoic acid (52107-87-6) + 2-thiocresol (137-06-4) → 3-methyl-4-[(2-methylphenyl)thio]benzoic acid

Conditions	Yield
Stage #1: 4-iodo-3-methylbenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane	100%

2-Iodobenzoic acid (88-67-5) + 2-thiocresol (137-06-4) → 2-(2'-Methylphenylthio)benzoic acid (87548-96-7)

Conditions	Yield
With potassium hydroxide; copper In water for 7h; Heating;	99%

methanol (67-56-1) + 2-thiocresol (137-06-4) → 2-methylbenzenesulfinic acid methyl ester (94626-19-4)

Conditions	Yield
With N-Bromosuccinimide In dichloromethane at 0℃; for 1h;	99%
With oxygen; potassium carbonate at 60℃; for 24h; Schlenk technique; chemoselective reaction;	75%
With eosin at 20℃; for 1h; Irradiation;	75%
(i) Pb(OAc)4, (ii) /BRN= 1098229/, Pb(OAc)4; Multistep reaction;

2-thiocresol (137-06-4) + 5-Isopropyl-6-methanesulfonyl-1-propoxy-1H-pyrimidine-2,4-dione (191472-62-5) → 5-Isopropyl-1-propoxy-6-o-tolylsulfanyl-1H-pyrimidine-2,4-dione

Conditions	Yield
With sodium hydroxide for 0.333333h; Ambient temperature;	99%

2-thiocresol (137-06-4) + 6-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate (345948-96-1) → C17H14O2S (627100-56-5)

Conditions	Yield
With triethylamine In dichloromethane at 20 - 25℃;	99%

N-tosyldiphenylmethylamine (853-83-8) + 2-thiocresol (137-06-4) → benzhydryl-o-tolyl sulfide

Conditions	Yield
With chloro-trimethyl-silane; zinc(II) chloride In dichloromethane at 20℃; for 1h;	99%

cyclohexenone (930-68-7) + 2-thiocresol (137-06-4) → (S)-3-(o-tolylthio)cyclohexanone (177473-06-2)

Conditions	Yield
With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)urea In toluene at 20℃; for 7h; Michael addition; optical yield given as %ee; enantioselective reaction;	99%

2-bromoanisole (578-57-4) + 2-thiocresol (137-06-4) → 2-methoxyphenyl 2-methylphenyl sulfide (105510-24-5)

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine In toluene for 3h; Inert atmosphere; Reflux;	99%
With 1-(pyridin-2-yl)-1H-benzo[d][1,2,3]triazole; potassium tert-butylate; palladium diacetate In dimethyl sulfoxide at 100℃; for 12h; Inert atmosphere; Schlenk technique;	87%
With copper(l) iodide; 1-Hydroxymethyl-1H-benzotriazole; potassium tert-butylate In dimethyl sulfoxide at 100℃;	78%

2-Bromo-m-xylene (576-22-7) + 2-thiocresol (137-06-4) → (2,6-dimethylphenyl)(o-tolyl)sulfane (38630-01-2)

Conditions	Yield
Stage #1: 2-Bromo-m-xylene With dichloro[1,3-bis(2,6-di-3-pentylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II); lithium isopropoxide In toluene at 80℃; for 0.5h; Inert atmosphere; Stage #2: 2-thiocresol With potassium tert-butylate In toluene at 40℃; for 24h; Inert atmosphere;	99%

2-thiocresol (137-06-4) + rac-2-(2-bromophenyl)-1-tosylaziridine (200803-17-4) → 3-(o-tolylthio)-1-tosylindoline (1429656-46-1)

Conditions	Yield
Stage #1: 2-thiocresol; 2-(2-bromophenyl)-N-tosylaziridine With potassium carbonate In toluene at 20℃; for 0.416667h; Inert atmosphere; Stage #2: With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110 - 115℃; for 3h; Inert atmosphere;	99%

Benzoylformic acid (611-73-4) + 2-thiocresol (137-06-4) → S-(o-tolyl) benzothioate

Conditions	Yield
With dipotassium peroxodisulfate In water; acetonitrile at 70℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;	99%
With ammonium peroxydisulfate; copper(II) oxide In water; dimethyl sulfoxide at 80℃; for 12h;	73%

(4-methylphenyl)(oxo)acetic acid (7163-50-0) + 2-thiocresol (137-06-4) → S-o-tolyl 4-methylbenzothioate

Conditions	Yield
With dipotassium peroxodisulfate In water; acetonitrile at 70℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;	99%

2-oxo-2-o-tolylacetic acid + 2-thiocresol (137-06-4) → S-o-tolyl 2-methylbenzothioate (101093-42-9)

Conditions	Yield
With dipotassium peroxodisulfate In water; acetonitrile at 70℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;	99%

phenylhydrazine (100-63-0) + 2-thiocresol (137-06-4) → 2-(phenylthio)toluene (13963-35-4)

Conditions	Yield
With manganese(II)carbonate; C26H36N2O6; oxygen; potassium carbonate at 60℃; under 750.075 Torr; for 19h;	99%
With copper(II) nitrate trihydrate; 4,7-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,10-phenanthroline; oxygen; caesium carbonate In water at 100℃; under 760.051 Torr; for 36h; Schlenk technique; Green chemistry; chemoselective reaction;	95%

p-Methoxybenzoic anhydride (794-94-5) + 2-thiocresol (137-06-4) → 1-[(4-methoxyphenyl)thio]-2-methylbenzene (22894-90-2)

Conditions	Yield
With manganese; 1,3-bis-(diphenylphosphino)propane; sodium carbonate; nickel dichloride In toluene at 150℃; for 24h; Sealed tube; Inert atmosphere;	99%

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 95-49-8 2-methylchlorobenzene 
• 95-53-4 o-toluidine 
• 95-15-8 Benzo[b]thiophene 
• 32812-89-8 bis(benzenethiolato)lead(II) 
• 74-88-4 methyl iodide 
• 7305-14-8 S-o-tolyl dimethylcarbamothioate 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 882-33-7 diphenyldisulfane 
• 7664-93-9 sulfuric acid 
• 860755-47-1 (1-phenyl-vinyl)-o-tolyl sulfide 
• 4032-80-8 bis(2-methylphenyl)disulfide 
• 108-88-3 toluene 
• 624-92-0 Dimethyldisulphide 

Downstream Products

• 25508-64-9 1-(o-tolylmercapto-methyl)-piperidine 
• 109846-70-0 2-(2-o-tolylmercapto-ethyl)-pyridine 
• 7028-73-1 4-methylthio-1-(o-carboxybenzoyl)benzene 
• 122542-15-8 7-methyl-4-(β-o-tolylmercapto-phenethyl)-coumarin 
• 123936-67-4 4-(4-methoxy-β-o-tolylmercapto-phenethyl)-6-methyl-coumarin 
• 5427-09-8 o-tolyl-trityl sulfide 
• 103575-38-8 2-(o-tolylthio)acetonitrile 
• 108478-08-6 1-phenyl-2-(o-tolylthio)ethanone 
• 23405-48-3 4-methylthiobenzophenone 
• 19620-62-3 Bis<4-(methylthio)phenyl>phenylmethanol 
• 10436-57-4 S-(2-methylphenyl) thioacetate 
• 24309-31-7 1-methyl-2-prop-2-enylsulfanylbenzene 
• 59309-64-7 3-(o-tolylthio)propanenitrile 
• 63991-88-8 3-o-tolylsulfanyl-propane-1,2-diol 

Relevant articles and documents

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

The aromatic thiol compound (by machine translation)

[A] at a high rate, and, high purity aromatic thiol compound method. [Solution] the presence of metal sulfide, with a compound represented by formula (1), by a vapor phase reaction of hydrogen sulfide, (2) an aromatic thiol compound represented by the formula manufacturing method. (R are each independently, C1 a-4 alkyl group, a hydroxyl group, amino group, cyano group, nitro group, C1 a-2 alkoxy group or a halogen atom; n is an integer of 0 - 5; X is a halogen atom)[Drawing] no (by machine translation)

Palladium catalyzed synthesis of aryl thiols: Sodium thiosulfate as a cheap and nontoxic mercapto surrogate

A Pd-catalyzed coupling reaction of ArBr/ArCl/ArOTf with sodium thiosulfate takes place in presence of Cs2CO3 at 80 °C. The reaction mixture is directly treated with Zn/HCl to afford aryl thiols in good to excellent yields.