16728-01-1

Basic information

• Product Name: 1-(4-METHOXYPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID
• Synonyms: 1-(4-METHOXYPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID;1-(4-METHOXY-PHENYL)-CYCLOPROPANECARBOXYLIC ACID;TIMTEC-BB SBB005453;RARECHEM AL BO 1513;1-(4-methoxyphenyl)cyclopropane-1-carboxylic acid;1-(4-Methoxyphenyl)-1-cyclopropanecarboxylicacid,96%;4-(1-Carboxycycloprop-1-yl)anisole, 1-Carboxy-1-(4-methoxyphenyl)cyclopropane;1-(4-Methoxyphenyl)-1-cyclopropanecarboxylic acid, 96% 10GR
• CAS NO: 16728-01-1
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21
• EINECS: 240-788-5
• Product Categories: Carboxylic Acids;Carboxylic Acids;Ring Systems
• Mol File: 16728-01-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 127-132 °C
• Boiling Point: 288.19°C (rough estimate)
• Flash Point: 138.6 °C
• Appearance: White to almost white/Crystalline Powder
• Density: 1.1430 (rough estimate)
• Vapor Pressure: 1.99E-05mmHg at 25°C
• Refractive Index: 1.5340 (estimate)
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 4.37±0.20(Predicted)
• CAS DataBase Reference: 1-(4-METHOXYPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID(16728-01-1)
• EPA Substance Registry System: 1-(4-METHOXYPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID(16728-01-1)

Safety Data

• Safety Statements: 24/25-25-24
• Hazardous Substances Data: 16728-01-1(Hazardous Substances Data)

Usage

Chemical Properties

White to almost white crystalline powder

InChI:InChI=1/C11H12O3/c1-14-9-4-2-8(3-5-9)11(6-7-11)10(12)13/h2-5H,6-7H2,1H3,(H,12,13)/p-1

Upstream product

• 104-47-2 p-methoxybenzylnitrile 
• 39729-00-5 2-(4-methoxyphenyl)propenoic acid ethyl eter 
• 104173-40-2 1-(4-Methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester 
• 16728-00-0 1-(4-methoxyphenyl)cyclopropane-1-carbonitrile 
• 104173-38-8 2,2-Dibromo-1-(4-methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester 

Downstream Products

• 16728-02-2 1-(4-methoxyphenyl)-1-cyclopropane carboxylic acid chloride 
• 847604-47-1 1-(4-methoxy-phenyl)-cyclopropanecarboxylic acid methylamide 
• 301162-05-0 (R)-N-[1-[(hydroxyamino)carbonyl]-3-(methylthio)propyl]-1-(4-methoxyphenyl)cyclopropanecarboxamide 
• 869970-25-2 1-(4-hydroxyphenyl)cyclopropanecarboxylic acid 
• 16728-03-3 1-(4-Methoxyphenyl)cyclopropyl-1-carbinol 
• 944280-21-1 {1-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}methanol 
• 944280-15-3 [1-(3-iodo-4-methoxyphenyl)cyclopropyl]methanol 
• 4280-49-3 1,6-bis(4-methoxyphenyl)hexa-1,6-dione 
• 121-97-1 4-Methoxypropiophenone 
• 16031-51-9 1-(4-methoxyphenyl)cyclopropyl acetate 
• 1067187-62-5 2-chloro-1-(1-(4-methoxyphenyl)cyclopropyl)ethanone 
• 1189328-26-4 N-(5-(2-methoxybenzoyl)pyridin-2-yl)-1-(4-methoxylphenyl)cyclopropanecarboxamide 
• 952664-63-0 (E)-methyl 1-(3-(1-(acetoxyimino)ethyl)-4-hydroxyphenyl)cyclopropanecarboxylate 

Relevant articles and documents

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

Deamination Reactions, 45. Decomposition of 1-Arylcyclopropanediazonium Ions

1-Arylcyclopropanediazonium ions have been generated by alkaline cleavage of the analogous nitrosocarbamates in methanol.With increasing ?-donor capacity of the aryl groups, retention of the three-membered ring was enhanced while the stereoselectivity (as probed with the aid of 2-D labels) was diminished or entirely lost (4-methoxyphenyl).Where applicable, the stereoselectivity of ring opening is inferior to that of nucleophilic displacement.The data may be interpreted in terms of competing reactions (ks, kc, kΔ) of the cyclopropanediazonium ions.