1282547-38-9

Upstream product

• 3984-14-3 N,N-dimethylsulfamide 
• 1282554-13-5 2-[([3-(4-fluorophenyl)propyl]{[1-(4-methoxyphenyl)cyclopropyl]carbonyl}amino)methyl]-5-methyl-1,3-thiazole-4-carboxylic acid 
• 16728-01-1 1-(4-methoxyphenyl)-1-cyclopropanecarboxylic acid 
• 1282555-55-8 ethyl 2-({[3-(4-fluorophenyl)propyl]amino}methyl)-5-methyl-1,3-thiazole-4-carboxylate 
• 1282556-05-1 ethyl 2-[([3-(4-fluorophenyl)propyl]{[1-(4-methoxyphenyl)cyclopropyl]carbonyl}amino)methyl]-5-methyl-1,3-thiazole-4-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED AMIDE COMPOUND

[Problem] The present invention provides a substituted amide compound, such as a compound represented by the following structural formula, and the like, which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). [Means for Solving the Problem] The present inventors have made intensive studies on a compound having an antagonistic action against LPA receptor, and as a result, they have found that a substituted amide compound which is the compound of the present invention has an excellent antagonistic action against LPA receptor and is useful as an agent for preventing and/or treating diseases caused by LPA, thereby completing the present invention.

SUBSTITUTED AMIDE COMPOUND

A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optionally substituted lower alkyl, etc.