16728-63-5

Usage

Uses

Used in Pharmaceutical Industry:
3-(Cyclohexyloxy)propan-1-amine is used as a building block for the synthesis of various pharmaceuticals, due to its unique structural and chemical properties.
Used in Agrochemical Industry:
3-(Cyclohexyloxy)propan-1-amine is used as a building block for the synthesis of agrochemicals, contributing to the development of new and effective products.
Used in Specialty Chemicals Industry:
3-(Cyclohexyloxy)propan-1-amine is used as a building block for the production of specialty chemicals, enhancing the properties and performance of these chemicals.
Used in Metal-Organic Frameworks and Coordination Compounds:
3-(Cyclohexyloxy)propan-1-amine is used as a potential ligand in the synthesis of metal-organic frameworks and coordination compounds, due to its unique structural and chemical properties.
Used in Material Science:
3-(Cyclohexyloxy)propan-1-amine may have potential applications in the field of material science, contributing to the development of new materials with improved properties.
Used as a Reagent in Organic Chemistry Reactions:
3-(Cyclohexyloxy)propan-1-amine is used as a reagent in various organic chemistry reactions, facilitating the synthesis of complex organic compounds.

InChI:InChI=1/C9H19NO/c10-7-4-8-11-9-5-2-1-3-6-9/h9H,1-8,10H2

Upstream product

• 108-93-0 cyclohexanol 
• 823226-18-2 3-(cyclohexyloxy)-1-propanol methanesulfonate (ester) 
• 75322-09-7 3-cyclohexyloxypropyl alcohol 
• 27912-81-8 3-(cyclohexyloxy)propionic acid 
• 7170-38-9 3-phenoxypropanoic acid 
• 16728-52-2 3-cyclohexyloxy-propionitrile 

Downstream Products

• 200400-40-4 N-[1-(3-cyclohexyloxy-propylcarbamoyl)-2-hydroxy-ethyl]-4-(pyridine-3-carbonyl)-benzamide 
• 200400-48-2 (S)-2-[4-(Pyridine-3-carbonyl)-phenyl]-4,5-dihydro-oxazole-4-carboxylic acid (3-cyclohexyloxy-propyl)-amide 
• 200400-56-2 N-<3-(cyclohexyloxy)propyl>-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide 
• 200400-23-3 2-amino-N-(3-cyclohexyloxy-propyl)-3-hydroxy-propionamide 
• 71126-67-5 (3-cyclohexyloxy-propyl)-dimethyl-amine 

Relevant academic research and scientific papers

Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted ω-phenyl-ω-(3-pyridyl)alkenoic acid derivatives and related compounds

A novel series of oxazolecarboxamide-substituted ω-phenyl-ω-(3- pyridyl)alkenoic acid derivatives was discovered as potent dual-acting agents to block the TXA2 receptor and to inhibit the thromboxane synthase (TRA/TSI). Synthesis, structure-activity relationship (SAR), and in vitro and in vivo pharmacology of this series of compounds are described. Modification of the series revolved around the oxazole moiety to increase the hydrophilicity of the compounds and to correlate the biological activity with lipophilicity of the compounds. The most potent in the series was (E)-7-[4- [4-[[(4-cyclohexylbutyl)amino]carbonyl]-2-oxazolyl]phenyl]-7-(3-pyridyl)hept- 6-enoic acid (14) with K(d) = 9.9 ± 0.4 nM for the thromboxane receptor antagonism and IC50 = 55.0 ± 17.9 nM for thromboxane synthase inhibition. The compound 14 was a selective TRA/TSI which exhibited desirable characteristics for oral activity, 'shunt' effect to elevate PGI2 level, and absence of agonist activity.

Carbamoyl substituted heterocycles

This invention relates to carbamoyl substituted heterocycles which are ω-phenyl-ω-(3-pyridyl)-ω-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.

PREPARATION OF SUBSTITUTED ALKENOIC ACIDS

This invention relates to a highly selective process for preparation of E-ω-phenyl-ω-(3-pyridyl)-ω-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefor.

Carbamoyl substituted oxazoles as thromboxane receptor antagonists

This invention relates to carbamoyl substituted heterocycles which are ω-phenyl-ω-(3-pyridyl)-ω-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.

Polycyclic amines and intermediates therefor

This invention relates to a new method for the preparation of amines containing alkylene groups by using cyclic alkylene sulphuric esters, and novel intermediates for use in the method. The new method is useful for preparation of i.a. pharmaceuticals. The novel intermediates are useful i.a. as surfactants.