16732-71-1

Basic information

• Product Name: 7-Bromoindole-2-carboxylic acid
• Synonyms: 7-BROMOINDOLE-2-CARBOXYLIC ACID;7-BROMO-2-INDOLECARBOXYLIC ACID;7-BROMO-1H-INDOLE-2-CARBOXYLIC ACID
• CAS NO: 16732-71-1
• Molecular Formula: C₉H₆BrNO₂
• Molecular Weight: 240.05
• EINECS: 201-215-5
• Mol File: 16732-71-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 238-243°C
• Boiling Point: 470.9 °C at 760 mmHg
• Flash Point: 238.6 °C
• Appearance: /
• Density: 1.838 g/cm³
• Vapor Pressure: 1.13E-09mmHg at 25°C
• Refractive Index: 1.749
• Storage Temp.: 2-8°C
• PKA: 4.22±0.30(Predicted)
• CAS DataBase Reference: 7-Bromoindole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromoindole-2-carboxylic acid(16732-71-1)
• EPA Substance Registry System: 7-Bromoindole-2-carboxylic acid(16732-71-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 16732-71-1(Hazardous Substances Data)

Usage

General Description

7-Bromoindole-2-carboxylic acid is a chemical compound with the molecular formula C9H6BrNO2. It is an organic compound consisting of a bromoindole core with a carboxylic acid functional group attached at the 2-position. 7-Bromoindole-2-carboxylic acid is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules, such as potential pharmaceutical drugs. It is also used in the field of organic synthesis as a versatile intermediate for the preparation of other complex organic compounds. The presence of the bromine atom in the molecule lends to its unique reactivity and potential for diverse chemical transformations, making it a valuable tool for organic chemists in the development of new drugs and materials.

InChI:InChI=1/C9H6BrNO2/c10-6-3-1-2-5-4-7(9(12)13)11-8(5)6/h1-4,11H,(H,12,13)

Upstream product

• 16732-69-7 ethyl 7-bromo-1H-indole-2-carboxylate 
• 18474-55-0 2-(2-bromo-phenylhydrazono)-propionic acid ethyl ester 

Downstream Products

• 51417-51-7 7-bromo-1H-indole 
• 1217-60-3 7-phenylindole-2-carboxylic acid 
• 1169857-25-3 7-bromo-1H-indole-2-carboxylic acid benzyl ester 

Relevant articles and documents

Synthesis of 3,3-Dihalo-2-oxindoles from 2-Substituted Indoles via Halogenation–Decarboxylation/Desulfonamidation–Oxidation Process

A novel one-pot reaction which combines halogenation, decarboxylation/desulfonamidation with oxidation has been developed. Diverse valuable 3,3-dihalo-2-oxindole compounds can be produced rapidly and safely with isolated yields of up to 98% under mild conditions. (Figure presented.).

The first potent and selective non-imidazole human histamine H4 receptor antagonists

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.