167370-02-7Relevant academic research and scientific papers
The utilization of secondary phosphine oxide synthons for the preparation of novel tertiary phosphine oxide modified DNA
Collingwood, Stephen P.,Taylor, Roger J.
, p. 283 - 285 (2007/10/03)
Novel tertiary phosphine oxides are described which act as masked secondary phosphine oxides. The protection of the reactive P-H bond allows generation of a carbanion alpha to phosphorus and subsequent alkylation with an oxetane. The free P-H can then be liberated with anhydrous acid. This functionality can then be further alkylated to generate novel tertiary phosphine oxide backbone modified DNA.
