167372-09-0Relevant academic research and scientific papers
Substituent position-driven reaction pathways in the heterogeneous one-pot reduction/asymmetric hydrogenation of nitro-substituted (E)-2,3- diphenylpropenoic acids over Pd catalyst
Szoelloesi, Gyoergy,Bartok, Mihaly
, p. 16 - 27 (2012/03/11)
The reaction pathway in the heterogeneous enantioselective hydrogenation of nitro-substituted (E)-2,3-diphenylpropenoic acids over Pd catalyst modified by cinchonidine is determined by the position of the substituent. The reaction route was indicated by the H2 consumption curve and enantioselectivity of the final amino acid or 3-phenyl-1,2,3,4-tetrahydro-2- quinolone formed by intramolecular amidation. The obtained enantioselectivities were low with the exception of acids bearing nitro substituent in para position on the 3-phenyl moiety, the latter resulting in good, up to 80 % optical purity. The present study is the first to report the enantioselective heterogeneous catalytic preparation of 1,2,3,4-tetrahydro-2-quinolones and presents an attractive method for obtaining optically enriched 3-(4-aminophenyl)-2- phenylpropionic acids. ARKAT-USA, Inc.
FUSED PYRIMIDINE COMPOUNDS AND THEIR USE AS PHARMACEUTICALS
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, (2008/06/13)
Pharmaceutical compounds which are azolo-fused pyrimidine compounds having the formula STR1 in which =A--B--together with the pyrimidine ring forms a) a pyrazolo[1,5-a]pyrimidine of formula (A), STR2 b) a [1,2,4]triazolo[1,5-a]pyrimidine of formula (B), STR3 c) an imidazo[1,5-a]pyrimidine of formula (C), STR4 or d) an imidazo[1, 2-a]pyrimidine of formula (D), STR5
