167385-77-5

Upstream product

• 68754-16-5 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-methylbutan-1-one 
• 708-76-9 2-hydroxy-4,6-dimethoxybenzaldehyde 
• 500-99-2 3,5-dimethoxyphenol 
• 503-74-2 3-methylbutyric acid 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 

Downstream Products

• 167385-76-4 3,5-Dimethoxy-2-(3-methyl-1-phenylsulfanyl-butyl)-phenol 
• 870681-79-1 (+/-)-8-(3-methylbutyl)-5,7-dimethoxy-4-(4-methoxyphenyl)-3,4-dihydrocoumarin 
• 68754-17-6 2-(3-methylbutyl)-3,5-dimethoxyphenol 

Relevant academic research and scientific papers

The first total synthesis of sideroxylonal B

Sideroxylonal B (2c) has been synthesized through biomimetic cycloaddition of the o-quinone methide and the isopentenyl intermediates (5 and 6t), both of which were simultaneously derived from isopentenyl phloroglucinol precursor 4.

Regioselective synthesis and estrogenicity of (±)-8-alkyl-5,7- dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins

Nine new (±)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4- dihydrocoumarins have been synthesized from 2,4,6-trimethoxybenzaldehyde via a short, efficient, and regioselective pathway, together with the unsubstituted analogue (±)-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarin. The compounds were tested for estrogenic activity using a yeast-based estrogen screen. Weak estrogenicity was determined for seven members of the series.

Electrochemical synthesis of chroman and euglobal skeletons via cycloaddition reaction of o-quinone methides and alkenes

Euglobal skeletons were synthesized by the intermolecular cycloaddition reaction of terpenes and o-quinone methides generated in situ by electrochemical oxidation. In a two-phase reaction medium composed of hexane-lithium perchlorate/nitromethane, 2-[1-(p