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(E)-4-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-1-yl)-2-thiophenecarboxylic acid, also known as PMPA, is a potent and selective inhibitor of type 2 human immunodeficiency virus (HIV)-specific phosphonomethyl prodrug. It is a nucleotide reverse transcriptase inhibitor (NRTI) that has been used in the treatment of HIV infection, and it works by blocking the action of the enzyme reverse transcriptase, which is involved in the replication of the virus.

167413-66-3

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167413-66-3 Usage

Uses

Used in HIV Treatment:
PMPA is used as an antiviral agent for the treatment of HIV infection. It functions by inhibiting the enzyme reverse transcriptase, which is essential for the replication of the virus, thus helping to control the progression of the disease.
Used in Pre-exposure Prophylaxis (PrEP) for HIV:
PMPA has been studied as a potential pre-exposure prophylaxis for HIV, which means it could be used to prevent the acquisition of the virus in individuals who are at high risk of infection.
Used in Antiviral Research for Other Retroviruses:
PMPA has also been investigated for its antiviral activity against other retroviruses, such as simian immunodeficiency virus (SIV) and feline immunodeficiency virus (FIV), indicating its potential use in the treatment and prevention of these related viral infections.
Used in the Treatment of Other Viral Infections:
Additionally, PMPA has shown potential for the treatment of other viral infections, such as hepatitis B and Ebola, expanding its possible applications in the field of antiviral therapy.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, PMPA is used as a key compound in the development of new antiviral drugs, contributing to the ongoing research and innovation in the fight against viral diseases.
Overall, PMPA is a promising antiviral agent with a range of potential applications in the treatment and prevention of viral infections, making it a valuable asset in the medical and pharmaceutical fields.

Check Digit Verification of cas no

The CAS Registry Mumber 167413-66-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,4,1 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 167413-66:
(8*1)+(7*6)+(6*7)+(5*4)+(4*1)+(3*3)+(2*6)+(1*6)=143
143 % 10 = 3
So 167413-66-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H28O2S/c1-14(9-16-11-20(21(24)25)26-13-16)17-12-19-18(10-15(17)2)22(3,4)7-8-23(19,5)6/h9-13H,7-8H2,1-6H3,(H,24,25)/b14-9+

167413-66-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]thiophene-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names (E)-4-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-1-yl)-2-thiophenecarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:167413-66-3 SDS

167413-66-3Upstream product

167413-66-3Downstream Products

167413-66-3Relevant academic research and scientific papers

Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids

Beard,Chandraratna,Colon,Gillett,Henry,Marler,Song,Denys,Garst,Arefieg,Klein,Gil,Wheeler,Kochhar,Davies

, p. 2820 - 2829 (1995)

Retinoids elicit biological responses by activating a series of nuclear receptors. Six retinoid receptors belonging to two families are currently known: retinoic acid receptors (RAR(α,β,andγ)) and retinoid X receptors (RXR(α,β,andγ)). Stilbene retinoid an

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