1675-54-3

Usage

InChI:InChI=1/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3/t19-,20-/m1/s1

Upstream product

• 80-05-7 BPA 
• 106-89-8 epichlorohydrin 
• 4809-35-2 1-chloro-3-[4-[2-[4-(3-chloro-2-hydroxypropoxy)phenyl] propan-2-yl]phenoxy]propan-2-ol 
• 3739-67-1 bisphenol A diallyl ether 

Downstream Products

• 122118-96-1 2,2-bis-[4-(2,3-diacetoxy-propoxy)-phenyl]-propane 
• 21242-15-9 5,5′-(((propane-2,2-diylbis(4,1-phenylene))bis(oxy))bis-(methylene))bis(3-(p-tolyl)oxazolidin-2-one) 
• 20844-45-5 3,3'-dibutyl-5,5'-[4,4'-(1-methyl-ethane-1,1-diyl)-bis-phenoxymethyl]-bis-oxazolidin-2-one 
• 81214-95-1 1-[Benzyl-(1,4,6-trioxa-spiro[4.4]non-2-ylmethyl)-amino]-3-{4-[1-(4-{3-[benzyl-(1,4,6-trioxa-spiro[4.4]non-2-ylmethyl)-amino]-2-hydroxy-propoxy}-phenyl)-1-methyl-ethyl]-phenoxy}-propan-2-ol 
• 76002-91-0 2-[4-(2,3-epoxypropanyloxy)phenyl]-2-[4-(2,3-dihydroxypropanyloxy)phenyl]propane 

Relevant academic research and scientific papers

A starch based sustainable tough hyperbranched epoxy thermoset

With the growing concern of long term environmental and waste management problems, the recent trend in the polymer industry is aimed to utilize environmentally benign substrates for development of sustainable polymers with the required properties for their potential applications as substitutes for petrochemical derivatives. In this arena, the authors aspired to use starch, a natural renewable polysaccharide obtained from a wide variety of crops, as one of the reactants for a one-pot synthesis of a bio-based sustainable hyperbranched epoxy resin. Nuclear magnetic resonance (1H NMR and 13C NMR), Fourier transformed infrared spectroscopy (FTIR) along with different analytical techniques confirmed the chemical structure of the resin. The poly(amido amine) cured epoxy thermoset exhibited acceptable biodegradation along with desirable properties. It exhibits excellent impact resistance (>100 cm), outstanding scratch hardness (>10 kg), exceptionally high tensile adhesive strength (up to 2906 MPa for aluminum), moderate tensile strength (up to 29 MPa), good elongation at break (up to 38%), high toughness (up to 8.40 MJ m-3) and very good chemical resistance against a number of chemical environments. Moreover, the thermoset displayed potent biomedical attributes by exhibiting cytocompatibility with erythrocytes as assessed through a hemolytic assay. Thus, the synthesized eco-friendly and sustainable hyperbranched epoxy thermoset with good toughness and exceptional adhesive strength can be a worthy replacement for petroleum-based epoxy thermosets as an advanced engineering material.

Design and fabrication of a novel superhydrophobic surface based on a copolymer of styrene and bisphenol A diglycidyl ether monoacrylate

The copolymer of styrene and bisphenol A diglycidyl ether monoacrylate (PS-co-AADGEBA) was synthesized by three steps from raw materials, and then it was used to fabricate a superhydrophobic surface via a phase separation method. In particular the superhydrophobic surface not only exhibits superhydrophobicity towards water and corrosive liquids, including acidic and basic solutions, but also shows good transparency, improved robustness and excellent aging resistance. Furthermore, the PS-co-AADGEBA was also successfully grafted onto the surface of amino-functionalized hollow silica nanospheres (HSNs-NH 2), then a (PS-co-AADGEBA)-g-(HSNs-NH2) nanocomposite superhydrophobic surface was prepared. The obtained surfaces are promising materials for numerous potential application fields, including electronics, biomedical, martial and defense-related areas.

An in situ prepared photo-luminescent transparent biocompatible hyperbranched epoxy/carbon dot nanocomposite

A photo-luminescent transparent biocompatible hyperbranched epoxy/carbon dot nanocomposite was prepared by incorporation of carbon dots during formation of hyperbranched epoxy resin. The prepared nanocomposite was characterized by FTIR, NMR and TEM analyses. The poly(amido-amine) cured nanocomposite exhibited high tensile strength (62.5 MPa), high elongation at break (45%), good thermal stability (291 °C), high transparency and excellent wavelength dependent photoluminescence behavior along with biocompatibility with skin cells. The performance of this nanocomposite was also compared with the pristine hyperbranched epoxy as well as hyperbranched epoxy/carbon dot nanocomposite obtained through an ex situ solution technique. The study revealed that the in situ prepared nanocomposite possessed superior mechanical, optical and biocompatible properties compared to pristine epoxy as well as the ex situ prepared nanocomposite. Thus, the study will significantly contribute to the field of high performance transparent fluorescent polymeric materials used in optoelectronics. Good viability, spreading and proliferation of skin fibroblasts and keratinocyte cells on the nanocomposite suggest it is also a highly potential material for bio-sealant application.

HERBICIDE COMPOSITION COMPRISING CLOMAZONE AND USE THEREOF

A composition comprising a water-immiscible material or high volatile material encapsulated within a microcapsule is provided, the microcapsules having a shell comprising a polyurea cross-linked by epoxy resin polymer. The method for preparing the same, and the use of the same in the control of unwanted plant growth are also provided.

PROCESS FOR PRODUCTION OF EPOXY COMPOUND

To provide an efficient method of producing an epoxy compound comprising reacting hydrogen peroxide and acetonitrile with the carbon-carbon double bond of an organic compound having a carbon-carbon double bond. A method of producing an epoxy compound comprising epoxidizing the carbon-carbon double bond of an organic compound having a carbon-carbon double bond in the presence of acetonitrile by using hydrogen peroxide as an oxidizing agent, wherein the reaction proceeds while controlling the acetonitrile concentration in the reaction system in the range of 0.6-5 mol/L by using a solvent containing an alcohol.

PROCESS FOR PRODUCING EPOXY COMPOUND

According to the present, invention, a process for producing an epoxy compound, where an epoxy compound can be selectively produced from olefins with good yield at low cost in a safe manner by a simple operation under mild conditions without using a quaternary ammonium salt or a metal compound, is provided. The present invention relates to a process for producing an epoxy compound, comprising epoxidizing a carbon-carbon double bond of an organic compound having a carbon-carbon double bond by using hydrogen peroxide as an oxidant, wherein the epoxidation is carried by out using an organic nitrile compound and an organic amine compound.

METHOD OF PRODUCING EPOXY COMPOUNDS

Provided is a method of efficiently producing an epoxy compound from an allyl ether having an aromatic ring under mild conditions by using hydrogen peroxide as an oxidizing agent without using an organic solvent. The method of producing an epoxy compound comprises reacting an allyl ether having an aromatic ring with hydrogen peroxide to epoxidize a carbon-carbon double bond of an allyl group to thereby produce a corresponding epoxy compound having an aromatic ring, wherein water only is used as a solvent without using an organic solvent, and a tungsten compound, and a tertiary amine and/or a quaternary ammonium salt, are used as a reaction catalyst.

Structural optimization and biological evaluation of substituted bisphenol a derivatives as β-amyloid peptide aggregation inhibitors

The aggregation of A? is a crucial step in the etiology of Alzheimer's disease. Our previous work showed that A? undergoes ?-helix/?-sheet intermediate structures during the conformational transition, and an A? aggregation inhibitor (1) was discovered by targeting the intermediates. Here, structure optimization toward compound 1 was performed and 34 novel derivatives were designed and synthesized. Nine compounds showed more effective inhibitory activity than the hit compound 1 in ThT fluorescence assay. Among them, compound 43 demonstrated more excellent inhibitory potency, which not only can suppress the aggregation of A? but also can dissolve the preformed fibrils as shown by CD spectroscopy, PICUP and AFM assays. Cellular assay indicated that 43 has no toxicity to neuronal cells, moreover, can effectively inhibit A? 1?42-induced neutrotoxicity and increase the cell viability. Together, on the basis of these positive results, these novel chemical structures may provide a promising potential for therapeutic applications in AD and other types of neurodegenerative disorders.

DIGLYCIDIC ETHER DERIVATIVE THERAPEUTICS AND METHODS FOR THEIR USE

This invention provides compound having a structure of Formula I or Formula II. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.

Synthesis of novel poly(hydroxyether terephthalate) via polyaddition of 2,5-difluoroterephthalic acid with aromatic bis(epoxide)s

A novel and more reliable synthetic route to 2,5-difluoroterephthalic acid was developed. A series of new poly(hydroxyether terephthalate) were prepared by the polyaddition of 2,5-difluoroterephthalic acid with various aromatic bis(epoxide)s catalyzed by tetrabutyl ammonium bromide.