167545-91-7Relevant academic research and scientific papers
Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors
Hack, Silke,W?rlein, Babette,H?fner, Georg,Pabel, J?rg,Wanner, Klaus T.
experimental part, p. 1483 - 1498 (2011/05/11)
A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been synthesized and tested for the inhibitory potency at the
Indoline compound and 5-HT3 receptor antagonist containing the same as active ingredient
-
, (2008/06/13)
Indoline compounds represented by the general formula: STR1 wherein R1 represents the group STR2 R2 represents a phenyl group which may be substituted or an aromatic heterocyclic group, and R3 represents hydrogen, a halogen, or a lower alkyl group, hydroxyl group, lower alkoxy group, carbamoyl group or lower alkoxycarbonyl group, and physiologically acceptable salts thereof, and their solvates, as well as 5-HT3 receptor antagonists containing them as effective components. The indoline compounds of the invention have stronger antagonism against intestinal 5-HT3 receptors than known 5-HT3 receptor antagonists and also have excellent sustained action, making them useful as prophylactic or therapeutic agents against vomiting or irritancy induced by chemotherapy or radiation, irritable bowel syndrome, diarrhea, and the like.
