16759-03-8Relevant academic research and scientific papers
Iron-catalyzed direct alkenylation of 2-substituted azaarenes with N -sulfonyl aldimines via C-H bond activation
Qian, Bo,Xie, Pan,Xie, Yinjun,Huang, Hanmin
, p. 2580 - 2583 (2011)
A novel iron-catalyzed alkenylation of 2-substituted azaarenes through sp3 C-H bond activation has been developed. A favorable E2-elimination is proposed as a key step to cleavage of C-H and C-N bonds for the construction of a C=C bond in high stereoselectivity. This transformation represents an efficient way to synthesize 2-alkenylated azaarenes from simple starting materials.
Asymmetric Yttrium-Catalyzed C(sp3)?H Addition of 2-Methyl Azaarenes to Cyclopropenes
Luo, Yong,Teng, Huai-Long,Nishiura, Masayoshi,Hou, Zhaomin
, p. 9207 - 9210 (2017)
An enantioselective C?H addition to a C=C bond represents the most atom-efficient route for the construction of chiral carbon–carbon skeletons, a central research topic in organic synthesis. We herein report the enantioselective yttrium-catalyzed C(sp3)?H bond addition of 2-methyl azaarenes, such as 2-methyl pyridines, to various substituted cyclopropenes and norbornenes. This process efficiently afforded a new family of chiral pyridylmethyl-functionalized cyclopropane and norbornane derivatives in high yields and high enantioselectivities (up to 97 % ee).
