41251-37-0

Basic information

• Product Name: METHYL-D3-MAGNESIUM IODIDE
• Synonyms: METHYL-D3-MAGNESIUM IODIDE;Methyl-d3-magnesium iodide solution;METHYL-D3-MAGNESIUM IODIDE, 99+ ATOM % D , 1.0M SOLUTION IN DIETHYL ETHER;trideutero-methylmagnesium iodide;Methyl-d3-magnesium iodide solution 1.0 M in diethyl ether, 99 atom % D
• CAS NO: 41251-37-0
• Molecular Formula: CH₃IMg
• Molecular Weight: 169.26
• Mol File: 41251-37-0.mol
• Article Data: 6

Chemical Properties

• Flash Point: −40 °F
• Appearance: /
• Density: 0.871 g/mL at 25 °C
• BRN: 3587273
• CAS DataBase Reference: METHYL-D3-MAGNESIUM IODIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-D3-MAGNESIUM IODIDE(41251-37-0)
• EPA Substance Registry System: METHYL-D3-MAGNESIUM IODIDE(41251-37-0)

Safety Data

• Hazard Codes: F+,C,F
• Statements: 12-14/15-22-66-67-34-19-11
• Safety Statements: 16-36/37/39-43-45-26
• RIDADR: UN 3399 4.3/PG 1
• WGK Germany: 3
• F: 1-10
• Hazardous Substances Data: 41251-37-0(Hazardous Substances Data)

Usage

Uses

Methyl-d3-magnesium Iodide is used as a reagent in the synthesis of Anacetrapib-d3 (A637202); a labelled orally active and potent cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia.

InChI:InChI=1/CH3.HI.Mg/h1H3;1H;/q;;+1/p-1/i1D3;;/rCH3IMg/c1-3-2/h1H3/i1D3

Upstream product

• 21524-04-9 pyridino tribromogold 
• 865-50-9 iodomethane-d3 

Downstream Products

• 139607-04-8 2-<²H₃>methylpyrazine 
• 64750-99-8 3-methyl-3-buten-2-ol-1,1,1-d3 
• 55755-08-3 2-methyl-d₃-2-adamantol 
• 60126-98-9 2-hexanol-1,1,1-d3 
• 151039-18-8 1-dideuteromethylene-2,3,4,4,5,6-hexamethyl-2,5-cyclohexadiene 
• 53716-61-3 2-Butanol-1,1,1-d₃ 
• 76070-25-2 1,1-bis(trideuteriodimethyl)-1-silacyclobutane 
• 75296-02-5 syn-7-methyl-d3-2-norbornen-7-ol 
• 159754-93-5 1,1,1-trideuterio-2-octanol 
• 17537-32-5 2,2,2-trideuterio-1-phenylethanol 
• 190078-37-6 C₁₁H₁₁⁽²⁾H₃O 

Relevant articles and documents

Infrared Matrix Isolation Study of Magnesium Metal Atom Reactions. Spectra of an Unsolvated Grignard Species

Reactions of magnesium atoms with methyl halides in argon matrices have given rise to four product bands which can be assigned to a new chemical species, at 543, 1305, 2800, and 2892 cm-1.All four are hydrogenic in nature, and are assigned to the four vibrations of a C3v methyl group in the reaction product.Evidence is presented for insertion of the magnesium atom into the carbon-halogen bond of the methyl halide to form a species H3CMgX, for X = Cl, Br, I.Similar reactions were observed with calcium and strontium atoms, while zinc atoms did not react with methylhalides under these conditions.No evidence was detected for a strong polar covalent carbon-magnesium bond, suggesting that the unsolvated Grignard reagent formed here has a structure other than that of the solvated solution species.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Solvolysis of 2-Aryl-3,3-dimethyl-2-butyl p-Nitrobenzoates. β-Deuterium Kinetic Isotope Effects and the Linear Free Energy Relationships

Solvolysis of 2-aryl-3,3-dimethyl-2-butyl p-nitrobenzoates (4a-4d) and the 1,1,1-trideuterio derivatives (5a,5b,5c) in HFIP exhibited a high kinetic isotope effect, k(CH3)/k(CD3) = 1.90 at 60 deg C for the deactivating substrates 4c vs 5c.This effect decreased significantly with increasing electron releasing of the substituent on the aryl ring.Hammett-Brown treatment of the rate data for 4 yielded excellent linear relationships (r = 0.999) with ρ+ = -3.48.It is evident that the contribution of the α-methyl group to the stabilization of the cationic transition state is not constant.The approximation in the linear free energy relationship is discussed.