41251-37-0

Usage

Uses

Used in Pharmaceutical Industry:
Methyl-d3-magnesium iodide is used as a reagent for the synthesis of Anacetrapib-d3 (A637202), a labelled orally active and potent cholesterol ester transfer protein (CETP) inhibitor. methyl-d3-magnesium iodide is particularly effective in the treatment of atherosclerosis, specifically dyslipidemia, which is a condition characterized by abnormal levels of lipids (fats) in the blood. The use of methyl-d3-magnesium iodide in the synthesis of Anacetrapib-d3 allows for the development of a more targeted and effective treatment option for patients suffering from this condition.

InChI:InChI=1/CH3.HI.Mg/h1H3;1H;/q;;+1/p-1/i1D3;;/rCH3IMg/c1-3-2/h1H3/i1D3

Upstream product

• 865-50-9 iodomethane-d3 
• 21524-04-9 pyridino tribromogold 

Downstream Products

• 33923-74-9 1,2,4-Trimethyl-4-trideuteriomethyl-3-methylencyclobuten 
• 139607-04-8 2-<²H₃>methylpyrazine 
• 53432-36-3 C₈H₁₁⁽²⁾H₃O 
• 55755-08-3 2-methyl-d₃-2-adamantol 
• 73776-92-8 C₁₀H₁₅⁽²⁾H₃O 
• 74649-40-4 C₁₀H₁₇⁽²⁾H₃ 
• 24300-66-1 1-(1,1,1-trideuteromethyl)cyclobutan-1-ol 
• 60126-98-9 2-hexanol-1,1,1-d3 
• 25725-11-5 [D₉]-tert-butyl alcohol 
• 53001-22-2 tert-butanol-d10 
• 25319-53-3 α,α,α-trideutero-ortho-xylene 
• 75352-00-0 C₁₀H₁₅⁽²⁾H₃O 

Relevant academic research and scientific papers

Infrared Matrix Isolation Study of Magnesium Metal Atom Reactions. Spectra of an Unsolvated Grignard Species

Reactions of magnesium atoms with methyl halides in argon matrices have given rise to four product bands which can be assigned to a new chemical species, at 543, 1305, 2800, and 2892 cm-1.All four are hydrogenic in nature, and are assigned to the four vibrations of a C3v methyl group in the reaction product.Evidence is presented for insertion of the magnesium atom into the carbon-halogen bond of the methyl halide to form a species H3CMgX, for X = Cl, Br, I.Similar reactions were observed with calcium and strontium atoms, while zinc atoms did not react with methylhalides under these conditions.No evidence was detected for a strong polar covalent carbon-magnesium bond, suggesting that the unsolvated Grignard reagent formed here has a structure other than that of the solvated solution species.

Diphenylamino pyrimidine compound for inhibiting kinase activity

The invention provides a diphenylamino pyrimidine compound for inhibiting the kinase activity, and particularly provides a medicinal composition of a substituted diphenylamino pyrimidine compound andapplication thereof. The compound is a compound as shown in a formula (I) in the specification, or pharmaceutically acceptable salt, prodrug, hydrate thereof or solvent compound, crystal form, N-oxideand various diastereomers thereof. The compound can be used for treating diseases which can be treated with JAK2 kinase inhibitors.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Mechanistic studies on the thermal and photochemical decomposition of dimethyl(2,4-pentanedionato)gold(III) in solution

Mechanisms of the thermal and photochemical decomposition of dimethyl(2,4-pentanedionato)gold were examined by UV-visible and 1H NMR spectroscopies in solution. The formation of gold mirrors results from both the thermal and photochemical decomposition reactions. The thermal decomposition reaction is extremely solvent dependent and is not observed in non-coordinating, non-polar solvents (i.e. cyclohexane). The kinetics for thermal decomposition are observed to be first-order in gold complex disappearance although the solvent plays a critical role in the decomposition process. Decomposition by reductive elimination of ethane and protonation of the 2,4-pentandionate ligand are major reaction modes. The mechanism for reductive elimination is examined by deuterium labeling with the perdeuteriodimethylgold compound. The formation of ethane-d3 and traces of methane by reaction from the 50:50 mixture of (dimethyl-d0)-and (dimethyl-d6)(2,4-pentanedionato)gold indicates that free radicals are formed from the homolysis of gold-methyl bonds. On the basis of the ratio of ethane-d0 to ethane-d3, however, the reaction is believed to proceed predominantly via a concerted reductive elimination and, to a lesser extent, a free-radical mechanism simultaneously. On the other hand, the photochemical decomposition produces more 3-methyl-2,4-pentanedione and less ethane. In labeling studies, the ratio of ethane-d0 to ethane-d3 is also decreased and is indicative of the greater radical nature of the photolytic mechanism. The UV photolysis does not show the same solvent dependence to reaction as the pyrolysis does, although the observed product ratios do vary with solvent. Thus, solvent-cage effects may be important to the decomposition process.

Solvolysis of 2-Aryl-3,3-dimethyl-2-butyl p-Nitrobenzoates. β-Deuterium Kinetic Isotope Effects and the Linear Free Energy Relationships

Solvolysis of 2-aryl-3,3-dimethyl-2-butyl p-nitrobenzoates (4a-4d) and the 1,1,1-trideuterio derivatives (5a,5b,5c) in HFIP exhibited a high kinetic isotope effect, k(CH3)/k(CD3) = 1.90 at 60 deg C for the deactivating substrates 4c vs 5c.This effect decreased significantly with increasing electron releasing of the substituent on the aryl ring.Hammett-Brown treatment of the rate data for 4 yielded excellent linear relationships (r = 0.999) with ρ+ = -3.48.It is evident that the contribution of the α-methyl group to the stabilization of the cationic transition state is not constant.The approximation in the linear free energy relationship is discussed.

The application of resolution enhancement techniques to the study of factors affecting group frequencies - I. Coupling of symmetric methyl deformation frequencies in o-xylene

Deconvolution of methyl symmetric deformation frequencies of o-, m- and p-xylene yields a fully resolved doublet with 10 cm-1 spacing in o-xylene, but singlets in m- and p-xylene.Resolution enhancement of the methyl bending mode of 1-methyl-2--benzene yields a single band near 1380 cm-1.The relative intensity of the heavy to light band systems is 0.4.The data indicate that spatial coupling exists between the symmetric methyl deformation modes of o-xylene.