167631-58-5

Usage

Uses

Used in Pharmaceutical Applications:
3-IODOINDOLE-2-CARBOXYLIC ACID is used as a building block in the synthesis of biologically active molecules, making it valuable for the development of new pharmaceuticals.
Used in Organic Synthesis:
In the field of organic synthesis, 3-IODOINDOLE-2-CARBOXYLIC ACID serves as a versatile intermediate, enabling the preparation of a wide range of compounds for various applications.

InChI:InChI=1/C9H6INO2/c10-7-5-3-1-2-4-6(5)11-8(7)9(12)13/h1-4,11H,(H,12,13)

Upstream product

• 1477-50-5 Indole-2-carboxylic acid 

Downstream Products

• 1404118-38-2 N-tert-butyl-2-(4-chlorophenyl)-2-(10-iodo-1,4-dioxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)acetamide 

Relevant academic research and scientific papers

Intramolecular Heck coupling of alkenyl 3-iodoindole-2-carboxamide derivatives

Ethyl 2-(1-oxo-1,2,3,4,5,10-hexahydroazepino[3,4-b] indol-5-yliden)acetate derivative 1a has been synthesised in good yield from indole-2-carboxylic acid 2 via a stoichiometric intramolecular Heck reaction.

Combinatorial library of 3-aryl-1h-indole-2-carboxylic acid

Combinatorial libraries that contains various different 4, 5 fused 3-substituted-2-pyrrolocarboxylic acids for screening pharmacological activity and methods of synthesizing said libraries.

Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides

Combinatorial libraries that contain various different 4,5-fused-3-substituted-2-pyrrocarboxylic amides for screening pharmacological activity and methods of synthesizing said libraries.

Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them

Benzo-fused heterocyclic compounds having a 5-membered ring, processes for their preperation, their use as medicaments, their use as diagnostic agents and medicaments containing them. Benzo-fused heterocyclic compounds having a 5-membered ring, of the formula I STR1 where X is N or CR(6); Y is oxygen, S or NR(7); A and B together are a bond or are both hydrogen, if, at the same time, X is CR(6) and Y is NR(7), one of the substituents R(1) to R(6) is a --CO--N=C(NH2)2 group; the other respective substituents R(1) to R(6) are H, Hal or alkyl; up to two of the other substituents R(1) to R(6) are CN, NO2, N3, (C1 -C4)-alkoxy, CF3 ; up to one of the other substituents is R(8)--Cn H2n --Z-- or phenyl; R(7) is H, alk(en)yl or R(8)--Cn H2n --, and pharmaceutically tolerated salts there of, are described. A process f or the preparation of the compounds I which comprises reacting a compound of the formula II STR2 in which one of the substituents R(1)' to R(5)' is a --CO--L group and L is a leaving group which can easily be replaced nucleophilically, with guanidine, and, if appropriate, converting the product into the pharmacologically tolerated salt, furthermore is also described.