167645-15-0

Upstream product

• 5735-53-5 1,4-benzoxazine 
• 100-47-0 benzonitrile 
• 129042-10-0 1-(5-Benzoyl-2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-bromo-ethanone 
• 1582184-88-0 tert-butyl (10-oxo-7-phenyl-1,2,9,10-tetrahydro-3-oxa-8,10a-diazacyclohepta[de]naphthalen-9-yl)carbamate 
• 1582184-83-5 tert-butyl 9-hydroxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate 
• 1582184-82-4 3-amino-9-hydroxy-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one 
• 1582184-79-9 benzyl 9-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate 
• 54905-94-1 8-methoxy-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 3177-80-8 2-amino-3-methoxybenzoic acid 
• 167645-05-8 Acetic acid 10-oxo-7-phenyl-1,2,9,10-tetrahydro-3-oxa-8,10a-diaza-cyclohepta[de]naphthalen-9-yl ester 
• 167645-10-5 9-Hydroxy-7-phenyl-1,2-dihydro-9H-3-oxa-8,10a-diaza-cyclohepta[de]naphthalen-10-one 
• 129042-13-3 8-Oxy-7-phenyl-1,2-dihydro-9H-3-oxa-8,10a-diaza-cyclohepta[de]naphthalen-10-one 
• 129042-08-6 (3,4-Dihydro-2H-benzo[1,4]oxazin-5-yl)-phenyl-methanone 
• 1027898-22-1 Methanesulfonic acid 10-oxo-7-phenyl-1,2,9,10-tetrahydro-3-oxa-8,10a-diaza-cyclohepta[de]naphthalen-9-yl ester 

Downstream Products

• 1582185-31-6 (S)-9-amino-7-phenyl-1,2-dihydro-3-oxa-8,10a-diazacyclohepta[de]naphthalen-10(9H)-one 

Relevant academic research and scientific papers

TRICYCLIC HETEROCYCLIC COMPOUNDS AS NOTCH INHIBITORS

Disclosed are compounds of Formula (I), wherein: X is O or -NR3; R1 is -CH2CH2CH3, -CH2CF3, -CH2CH2CF3, -CH2CF2CH3, -CH2CH2CH2CF3, -CH2CH2CF2CH3, -CH2CH(CH3)CF3, -CH2CH2CH2F, or CH2(cyclopropyl); R2 is -CH2CH2CH3, -CH2CF3, -CH2CH2CF3, -CH2CF2CH3, -CH2CH2CH2CF3, -CH2CH2CH2F, -CH2CH(CH3)CF3, CH2CH2CF2CH3, -CH2(cyclopropyl), -CH(CH3)(cyclopropyl), phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, pyridinyl, formula (i), formula (ii), formula (iii), formula (iv) or formula (v); Ring A is phenyl or pyridinyl; and R3, Ra, Rb, Rc, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.

Studies on a novel, potent and orally effective cholecystokinin A antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds

We prepared various novel tricyclic 1,4-benzodiazepine derivatives as cholecystokinin (CCK) A antagonists, which were evaluated preliminarily for inhibition of 125I-CCK-8 binding to rat pancreatic membranes in vitro and inhibiting effect on CCK

Tricyclic compounds

Tricyclo benzodiazepines are cholecystokinin antagonists.