16766-30-6

Basic information

• Product Name: 4-CHLORO-2-METHOXYPHENOL
• Synonyms: 4-chloro-2-methoxy-pheno;4-CHLORO-2-METHOXYPHENOL;4-CHLOROGUAIACOL;4-CHLORO-2-METHOXYPHENOL, TECH.;4-Chloropyrocatecholmonomethylether;PHENOL,4-CHLORO-2-METHOXY;4-Chloro-2-methoxyphenol,99%;5-Chloro-2-hydroxyanisole, 4-Chloroguaiacol
• CAS NO: 16766-30-6
• Molecular Formula: C₇H₇ClO₂
• Molecular Weight: 158.58
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Phenol&Thiophenol&Mercaptan;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Phenols;Organic Building Blocks;Oxygen Compounds
• Mol File: 16766-30-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 16-17 °C(lit.)
• Boiling Point: 241 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear pale yellow to light brown/Liquid
• Density: 1.304 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0218mmHg at 25°C
• Refractive Index: n20/D 1.559(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.52±0.18(Predicted)
• Water Solubility: It is slightly soluble in water.
• BRN: 1940516
• CAS DataBase Reference: 4-CHLORO-2-METHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHOXYPHENOL(16766-30-6)
• EPA Substance Registry System: 4-CHLORO-2-METHOXYPHENOL(16766-30-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 16766-30-6(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR PALE YELLOW TO LIGHT BROWN LIQUID

Uses

4-Chloro-2-methoxyphenol, is used as an intermediate in pharmaceutical research, pharmaceutical chemicals and reagents. It is also used as an application intermediate. it can be used to produce 4-Chloro-2-methoxy-6-nitrophenol.

InChI:InChI=1/C7H7ClO2/c1-10-7-4-5(8)2-3-6(7)9/h2-4,9H,1H3

Upstream product

• 851344-49-5 1-(allyloxy)-4-chloro-2-methoxybenzene 
• 504-29-0 2-aminopyridine 
• 90-05-1 2-methoxy-phenol 
• 93-50-5 4-chloro-o-anisidine 
• 3251-56-7 2-methoxy-4-nitrophenol 

Downstream Products

• 16766-27-1 4-chloro-1,2-dimethoxybenzene 
• 913837-99-7 1-(3-chloro-propoxy)-4-chloro-2-methoxybenzene 
• 912853-03-3 [2-(4-chloro-2-methoxyphenoxy)phenyl]acetic acid 
• 871103-28-5 3-chloro-4-(4-chloro-2-methoxyphenoxy)benzonitrile 

Relevant articles and documents

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Synthesis method 5 - halogeno-veratraldehyde

The invention belongs to the field of organic chemistry, and in particular relates 5 - to a method for synthesizing halogenated O-veratraldehyde by using 4 - halogenoylguaiacol as a raw material to obtain 2 -hydroxy -3 - methoxy -5 -halogenated mandelic a

Method for synthesizing eugenol

A method for synthesizing eugenol comprises the steps that firstly, guaiacol, lithium chloride and a catalytic amount of copper chloride are dissolved in glacial acetic acid, bubbling is conducted, oxygen is introduced for a reaction, and 4-chloro-2-methoxyphenol is obtained; then, 4-chloro-2-methoxyphenol reacts with alkyl halide alkyl ether in the presence of alkali to obtain 4-chloro-2-methoxy-1-alkoxy alkylphenol; 4-chloro-2-methoxy-1-alkoxy alkylphenol reacts with allyl magnesium halide in an ether solution to obtain 4-allyl-2-methoxy-1-alkoxy alkylphenol; and finally, 4-allyl-2-methoxy-1-alkoxy alkylphenol and p-toluenesulfonic acid monohydrate react in an organic solvent, and after the organic solvent is removed, residues obtained are subjected to high vacuum distillation to obtainthe eugenol product. According to the method, the problems that in the prior art, guaiacol directly reacts with 3-chloropropene to easily generate ortho-isomers difficult to separate, and the yield ofthe para-product eugenol is low are successfully solved, the quality of the eugenol product is improved, and the yield of eugenol is increased to 70% or above.

Directed Structural Transformations of Coordination Polymers Supported Single-Site Cu(II) Catalysts to Control the Site Selectivity of C-H Halogenation

A main difficulty in C-H bond functionalization is to undertake the catalyst control accurately where the reaction takes place. In this work, to achieve highly effective and regioselective single-site catalysts, a three-dimensional (3D) rhombus-like framework of {[Mn(Hidbt)DMF]·H2O}n (1) [H3idbt = 5,5′-(1H-imidazole-4,5-diyl)-bis(2H-tetrazole)] containing coordinated DMF molecules was constructed. For the dissolution-recrystallization structural transformation process, attractive structural transformations proceeded from 1 to a new crystalline species formulated as {[Mn3(idbt)2(H2O)2]·3H2O}n (2) with a 3D windowlike architecture, and then the Mn ions in 2 could be exchanged with Cu ions through cation exchange in a single-crystal to single-crystal fashion to produce the Cu-exchanged product {[Mn2Cu(idbt)2(H2O)2]·3H2O}n (2a), which had a windowlike framework like that of 2. Furthermore, 2 and 2a were used as heterogeneous catalysts for the regioselective C-H halogenation of phenols with N-halosuccinimides (NCS and NBS) to produce the site selective single monohalogenated products. It was found that the catalytic activity and site selectivity of 2a were much higher than those of 2, because the unique structural features of 2a with the uniformly dispersed CuII active centers served as a single-site catalyst with a site-isolated and well-defined platform to promote the C-H halogenation reaction in regiocontrol and guide an orientation that favored the para selectivity during the reaction process.