16766-27-1

Usage

Uses

Used in Pharmaceutical Industry:
4-chloro-1,2-dimethoxy-benzene is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex organic molecules that possess therapeutic properties.
Used in Organic Dyes Industry:
In the production of organic dyes, 4-chloro-1,2-dimethoxy-benzene is utilized as a key component due to its chemical structure that can be modified to create a range of colorants for different applications.
Used in Fragrance Industry:
4-chloro-1,2-dimethoxy-benzene is employed as a building block in the creation of fragrances, leveraging its chemical properties to develop scents for various consumer products.
Used as a Reagent in Organic Synthesis:
4-chloro-1,2-dimethoxy-benzene serves as a reagent in organic synthesis, facilitating chemical reactions that are essential for the production of a wide array of organic compounds.

InChI:InChI=1/C8H9ClO2/c1-10-7-4-3-6(9)5-8(7)11-2/h3-5H,1-2H3

Upstream product

• 2138-22-9 4-chloro-1,2-benzenediol 
• 91-16-7 1,2-dimethoxybenzene 
• 74-88-4 methyl iodide 
• 6315-89-5 3,4-dimethoxyaniline 
• 16766-30-6 4-Chloroguaiacol 
• 77-78-1 dimethyl sulfate 
• 5653-65-6 1-(3,4-dimethoxyphenyl)ethanol 
• 186581-53-3 diazomethane 
• 2772-46-5 4,5-Dichlor-brenzcatechindimethylether 

Downstream Products

• 140665-33-4 (2-Chloro-4,5-dimethoxy-phenyl)-thiophen-2-yl-methanone 
• 140665-32-3 (2-Chloro-4,5-dimethoxy-phenyl)-o-tolyl-methanone 
• 161199-98-0 1-(2-chloro-4,5-dimethoxyphenyl)-1-ethanone 
• 93900-92-6 2'-Chlor-2-(4-chlor-phenyl)-4',5'-dimethoxy-acetophenon 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 959706-64-0 4-(benzyloxy)-2-(3,4-dimethoxyphenyl)butanal 
• 1512855-70-7 N-(3,4-dimethoxyphenyl)-N-(3-methoxy-4-methylphenyl)-benzylamine 
• 51971-07-4 6-methyl-2,3,7-trimethoxy-9H-carbazole 
• 6315-89-5 3,4-dimethoxyaniline 
• 85525-23-1 2-chloro-4,5-dimethoxybenzophenone 
• 126644-86-8 5-chloro-1,2-dimethoxy-3-<2-(phenylsulfonyl)ethyl>benzene 
• 126644-85-7 1-chloro-3,4-dimethoxy-2-<2-(phenylsulfonyl)ethyl>benzene 
• 117882-38-9 2-chloro-4,5-dimethoxy-1,3-dinitro-benzene 
• 3899-65-8 1-chloro-4,5-dimethoxy-2-nitrobenzene 

Relevant academic research and scientific papers

Mild, Fast, and Easy to Conduct MoCl5-Mediated Dehydrogenative Coupling Reactions in Flow

A convenient and straightforward approach to performing oxidative coupling reactions in flow is presented. A collection of electron-rich benzene derivatives was subjected to this protocol, and the distinct utility of molybdenum pentachloride (MoCl5) is established. Using this unexplored protocol, biphenyls could be obtained in 21-91% isolated yield. This simple protocol opens a new chapter in reagent-mediated dehydrogenative coupling reactions, and yields are compared to classical approaches.

Mass Spectra of Chlorinated Veratroles (1,2-dimethoxybenzenes)

The behaviour of all nine chlorinated veratroles (1,2-dimethoxybenzenes) under electron impact has been investigated.The most common fragmentation processes are interpreted using metastable ion analysis and deuterium labelled compounds.For all compounds studied, the most common fragmentation route seems to be the primary loss of a methyl radical followed by loss of carbon monoxide.The ion formed has a well-known quinonoid structure and fragments by several routes elucidated by metastable ion analysis.In general, the spectra of the positional isomers are shown to be practically similar and it is apparent the e.g. the 3- and 4-chloro isomers can be differentiated only from the abundance ratio of the +. and + ions.

Efficient halogenation synthesis method of aryl halide

The invention discloses an efficient halogenation synthesis method of aryl halide. The method comprises the following step: in the presence of a catalyst (sulfoxide or oxynitride), a halogenation reagent and a solvent, carrying out a halogenation reaction on an aromatic ring compound to obtain the aryl halide. According to the present invention, in the presence of a catalyst (sulfoxide or nitrogenoxide), a halogenation reagent and a solvent, the aromatic ring is subjected to an efficient halogenation reaction, such that the very useful aryl halide can be obtained with high activity and high selectivity; and by adopting the method disclosed by the invention, aryl halides can be efficiently synthesized, and the method has a wide application prospect in actual production.

QUINAZOLINONE COMPOUNDS

New quinazolinone compounds are disclosed, as well as pharmaceutical compositions containing quinazolinones and methods for the treatment of diseases and conditions associated with mitochondrial dysfunction.

Syntheses of the fungal metabolites Boletopsins 7, 11, and 12 from the Papua New Guinea medicinal mushroom Boletopsis sp.

Boletopsins 7 (1), 11 (2), and 12 (3) are p-terphenyl dibenzofuran compounds, isolated from the Papua New Guinean medicinal mushroom Boletopsis sp. The first syntheses of these fungal metabolites are reported, allowing for an investigation of their antibiotic activity. The key steps include sequential Suzuki-Miyaura couplings to rapidly form the p-terphenyl backbone and an Ullmann ether synthesis on a formate ester to create the dibenzofuran moiety. Biological evaluation of the synthetic compounds and intermediates against a panel of bacterial nosocomial pathogens was performed.

Halogenated volatiles from the fungus Geniculosporium and the actinomycete Streptomyces chartreusis

Two unidentified chlorinated volatiles X and Y were detected in headspace extracts of the fungus Geniculosporium. Their mass spectra pointed to the structures of a chlorodimethoxybenzene for X and a dichlorodimethoxybenzene for Y. The mass spectra of some constitutional isomers for X and Y were included in our databases and proved to be very similar, thus preventing a full structural assignment. For unambiguous structure elucidation all possible constitutional isomers for X and Y were obtained by synthesis or from commercial suppliers. Comparison of mass spectra and GC retention times rigorously established the structures of the two chlorinated volatiles. Chlorinated volatiles are not very widespread, but brominated or even iodinated volatiles are even more rare. Surprisingly, headspace extracts from Streptomyces chartreusis contained methyl 2-iodobenzoate, a new natural product that adds to the small family of iodinated natural products.

NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES

[Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO2-Y -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.

PROTEIN KINASE INHIBITORS

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the structure (I) including stereoisomers, prodrugs and pharmaceutically accep

Grindstone chemistry: (Diacetoxyiodo)benzene-mediated oxidative nuclear halogenation of arenes using NaCl, NaBr or I2

A technique of "Grindstone chemistry" is applied to the solvent-free halogenation of arenes with NaCl, NaBr or I2 using (diacetoxyiodo)benzene as the oxidant. Improved yields and higher purities of the products are observed compared with those from established methods.

Efficient halogenation of aromatic systems using N-halosuccinimides in ionic liquids

A simple, rapid and highly regioselective green protocol has been developed for the halogenation of aromatic systems with N-halosuccinimides using room temperature ionic liquids (ILs) as novel and recyclable reaction media to produce the corresponding halogenated aromatic compounds in high to quantitative yields. N-Halosuccinimides show enhanced reactivity in ionic liquids thereby reducing the reaction times dramatically and improving the yields substantially.