167684-01-7Relevant academic research and scientific papers
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues
H?gberg, Marita,Sahlberg, Christer,Engelhardt, Per,Noréen, Rolf,Kangasmets?, Jussi,Johansson, Nils Gunnar,?berg, Bo,Vrang, Lotta,Zhang, Hong,Sahlberg, Britt-Louise,Unge, Torsten,L?vgren, Seved,Fridborg, Kerstin,B?ckbro, Kristina
, p. 4150 - 4160 (1999)
The further development of allosteric HIV-1 RT inhibitors in the urea analogue series of PETT (phenylethylthiazolylthiourea) derivatives is described here. The series includes derivatives with an ethyl linker (1-5) and racemic (6-16) and enantiomeric (17-
Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors
Sahlberg, Christer,Noreen, Rolf,Engelhardt, Per,Hoegberg, Marita,Kangasmetsae, Jussi,Vrang, Lotta,Zhang, Hong
, p. 1511 - 1516 (2007/10/03)
A series of potent specific HIV-1 RT inhibitory compounds is described. The compounds are urea analogs of PETT (PhenyEthylThiazoleThiourea) derivatives and the series includes derivatives with an ethyl linker (1-6) and conformationally restricted analogs (7-13). The antiviral activity is determined both at the RT level and in cell culture on both native and mutant forms of HIV-1. Many compounds display activity in the nM range against wt- RT.
