167693-61-0

Upstream product

• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 928150-62-3 N-(α,α-difluorobenzyl)pyrrolidine 
• 614-16-4 Benzoylacetonitrile 
• 100-52-7 benzaldehyde 
• 257296-58-5 N-((S)-1-hydroxymethyl-3-methyl-butyl)-benzamide 
• 3389-54-6 n-benzoylpyrrolidine 
• 100-47-0 benzonitrile 

Downstream Products

• 167693-62-1 (-)-(4S)-4,5-Dihydro-2-<2'-(diphenylphosphino)phenyl>-4-isobutyloxazole 

Relevant academic research and scientific papers

Efficient one-pot synthesis of 2-oxazolines from benzoylacetonitrile and β-aminoalcohols mediated by ZnCl2

A series of 2-oxazolines were synthesized using a simple, one-pot method under inert, moisture-free conditions from the benzoylacetonitrile and β-aminoalcohols mediated by 115-172 mol% ZnCl2. Structures of products were fully characterized by NMR, IR and MS. [Figure not available: see fulltext.]

Transition metal and base free synthesis of 2-aryl-2-oxazolines from aldehydes and β-amino alcohols catalysed by potassium iodide

Synthesis of 2-aryl-2-oxazolines from β-amino alcohols and aldehydes was achieved in good to excellent yield by employing a potassium iodide (KI)-tert-butyl hydroperoxide (TBHP) catalytic system. This protocol is very mild, metal and base free and can be performed under ambient reaction conditions. This oxidative cyclization strategy was further extended for the synthesis of optically active 2-oxazolines, which can act as very useful chiral auxiliaries and as ligands. This journal is

Synthesis of 2-oxazolines and related N-containing heterocycles using [Et2NSF2]BF4 as a cyclodehydration agent

The preparation of 2-oxazolines and related N-containing heterocycles from the corresponding hydroxyamides using XtalFluor-E ([Et2NSF 2s]BF4) as a cyclodehydration agent is described. A wide range of heterocycles are obtai

β-Amidoaldehydes via oxazoline hydroformylation

4-Substituted oxazolines, which are readily synthesized from naturally occurring α-amino acids, are converted efficiently and stereospecifically to β-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl.

METHOD FOR PRODUCING 2-OXAZOLINE ANALOGUE OR 1,3-OXAZINE ANALOGUE

The present invention is a method for producing a 2-oxazoline analogue or a 1,3-oxazine analogue represented by the following general formula (3) by reacting a 1,2-aminoalcohol compound or a 1,2-aminothiol compound with an α,α-dihaloamine compound. (In the formula, n represents 0 or 1, and R represents an oxygen atom or a sulfur atom. R1, R2 and R3 each represents an atom or a group shown in Group 1 to Group 3, and R° represents an atom or a group shown in Group 2 or Group 3. Two or more of R1, R2 and R3 may be bonded to each other to form a ring. Group 1: a hydrogen atom, a halogen atom, a nitro group, a cyano group, a formyl group, a carboxyl group, a sulfonyl group, a sulfinoyl group or a sulfenyl group; Group 2: an alkyl group, which may have an arbitrary substituent, an aryl group or an aralkyl group; and Group 3: an alkyl-substituted, aryl-substituted or aralkyl-substituted oxy group, a carbonyl group, an oxycarbonyl group, a carbonyloxy group, a thio group, a sulfonyl group, a sulfinoyl group or a sulfenyl group)

A facile synthesis of oxazolines, thiazolines, and imidazolines using α,α-difluoroalkylamines

β-Amino alcohols, β-amino thiols, and β-diamines can be converted to the corresponding oxazoline, thiazoline, and imidazoline derivatives, respectively, by reaction with α,α-difluoroalkylamines under mild conditions. The reaction is applicable for the synthesis of optically active heterocyclic compounds. Georg Thieme Verlag Stuttgart.

Synthesis of chiral (phosphinoaryl)oxazolines, a versatile class of ligands for asymmetric catalysis

Enantiomerically pure 2-oxazolines are readily prepared from 2-bromobenzonitrile by transmetalation with BuLi, subsequent reaction with chlorodiphenylphosphine and conversion of the resulting phosphinoaryl nitrile to the oxazoli