167752-26-3Relevant academic research and scientific papers
Total synthesis of the thiopeptide antibiotic amythiamicin D
Hughes, Rachael A.,Thompson, Stewart P.,Alcaraz, Lilian,Moody, Christopher J.
, p. 15644 - 15651 (2005)
The thiopeptide (or thiostrepton) antibiotics are a class of sulfur containing highly modified cyclic peptides with interesting biological properties, including reported activity against MRSA and malaria. Described herein is the total synthesis of the thi
Biosynthesis inspired Diels-Alder route to pyridines: synthesis of the 2,3-dithiazolylpyridine core of the thiopeptide antibiotics.
Moody, Christopher J,Hughes, Rachael A,Thompson, Stewart P,Alcaraz, Lilian
, p. 1760 - 1761 (2007/10/03)
Reaction of serine derived 1-alkoxy-2-azadienes with dehydroalanine derived dienophiles results in Diels-Alder reaction and aromatisation to give 2,3,6-trisubstituted pyridines, thereby establishing the viability of the proposed biosynthetic route to the
