167757-46-2

Basic information

• Product Name: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate
• Synonyms: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate;Piperidine-4-thiocarboxamide, N1-CBZ protected;Piperidine-4-thiocarboxamide, N1-CBZ protected 97%;N1-CBZ-PIPERIDINE-4-THIOCARBOXAMIDE;Benzyl 4-(Aminocarbonothioyl)-piperidine-1-carboxylate;Piperidine-4-thiocarboxamide,N1-CBZprotected97%;Benzyl 4-carbamothioylpiperidine-1-carboxylate;Benzyl 4-[Amino(Thiocarbonyl)]Piperidine-1-Carboxylate(WX619901)
• CAS NO: 167757-46-2
• Molecular Formula: C₁₄H₁₈N₂O₂S
• Molecular Weight: 278.36992
• Mol File: 167757-46-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 128 °C
• Boiling Point: 441.9 °C at 760 mmHg
• Flash Point: 221.1 °C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 5.24E-08mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• CAS DataBase Reference: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate(167757-46-2)
• EPA Substance Registry System: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate(167757-46-2)

Safety Data

• Hazard Codes: Harmful:
• Hazardous Substances Data: 167757-46-2(Hazardous Substances Data)

Usage

General Description

Benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate is a chemical compound with a complex structure. It consists of a benzene ring attached to a piperidine ring, with an amino group and a thiocarbonyl group bonded to the piperidine ring. The carboxylic acid group is also attached to the piperidine ring. benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate may have various uses, such as in organic synthesis, pharmaceutical research, or as a building block for other chemical compounds. Its specific properties and potential applications would depend on the context and the intended use in a given chemical reaction or product.

InChI:InChI=1/C14H18N2O2S/c15-13(19)12-6-8-16(9-7-12)14(17)18-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H2,15,19)

Upstream product

• 19172-47-5 Lawessons reagent 
• 167757-45-1 4-Carbamoylpiperidine-1-carboxylic acid benzyl ester 
• 39546-32-2 4-carboxamidopiperidine 
• 501-53-1 benzyl chloroformate 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 189695-66-7 2-[1-(phenylmethoxycarbonyl)-4-piperidyl]-4-ethoxycarbonyl-1,3-thiazole 
• 1394939-79-7 benzyl-4-[4-(3-{[(2,5-difluorophenyl)sulfonyl](methoxymethyl)amino}-2-fluorophenyl)-5-(pyridin-4-yl)-1,3-thiazol-2-yl]piperidine-1-carboxylate 
• 1394938-39-6 2,5-difluoro-N-{2-fluoro-3-[2-(1-methylpiperidin-4-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide 
• 866785-62-8 C₁₆H₁₈N₂O₂S 

Relevant articles and documents

THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS

Thiazolylphenyl-benzenesulfonamido derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation

5-Membered heterocyclic compounds, of which the following compounds are exemplary: (a) 4-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-1-(4-piperidyl)imidazole, (b) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-thiazole, (c) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-thiazole, (d) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiazole, (e) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiazole, (f) 5-??trans-4-(carboxymethoxy)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (g) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (h) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, and (i) 4-??trans-4-carboxycyclohexyl!aminocarbonyl!-1-?2-(4-piperidyl)ethyl!imidazole. These are useful for the treatment or prevention of illnesses in which relatively small or relatively large cell aggregates occur or cell-matrix interactions play a part.