167757-45-1

Basic information

• Product Name: BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• Synonyms: N-Z-ISONIPECOTINAMIDE;4-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-N-CBZ-PIPERIDINE-4-CARBOXAMIDE;BUTTPARK 75\50-02;BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;1-Piperidinecarboxylic acid, 4-(aminocarbonyl)-, phenylmethyl ester;Benzyl 4-(aminocarbonyl)piperidine-1-carboxylate;1-Cbz-4-piperidinecarboxamide
• CAS NO: 167757-45-1
• Molecular Formula: C₁₄H₁₈N₂O₃
• Molecular Weight: 262.3
• Mol File: 167757-45-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 130 °C
• Boiling Point: 475.5°C at 760 mmHg
• Flash Point: 241.4°C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 3.3E-09mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.40±0.20(Predicted)
• CAS DataBase Reference: BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(167757-45-1)
• EPA Substance Registry System: BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(167757-45-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 167757-45-1(Hazardous Substances Data)

Usage

General Description

Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate is a chemical compound with a molecular formula C17H19N3O3. It is a derivative of tetrahydrofuran and is commonly used as a pharmaceutical intermediate. It is often used in the synthesis of various pharmaceutical drugs and may have potential therapeutic applications. The compound is classified as an ester, containing the benzyl ester group along with an aminocarbonyl group attached to a tetrahydro-1(2H)-pyridinecarboxylate moiety. Its precise chemical properties and potential uses may vary depending on the specific context and intended application.

InChI:InChI=1/C14H18N2O3/c15-13(17)12-6-8-16(9-7-12)14(18)19-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H2,15,17)

Upstream product

• 144-55-8 sodium hydrogencarbonate 
• 138163-07-2 piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-methyl ester 
• 39546-32-2 4-carboxamidopiperidine 
• 501-53-1 benzyl chloroformate 
• 1885-14-9 phenyl chloroformate 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 161609-84-3 4-cyanopiperidine-1-carboxylic acid benzyl ester 
• 1394938-39-6 2,5-difluoro-N-{2-fluoro-3-[2-(1-methylpiperidin-4-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide 
• 167757-46-2 benzyl-4-carbamothioylpiperidine-1-carboxylate 

Relevant articles and documents

Synthesis of Nitriles from Aldoximes and Primary Amides Using XtalFluor-E

The dehydration reaction of aldoximes and amides for the synthesis of nitriles using [Et2NSF2]BF4 (XtalFluor-E) is described. Overall, the reaction proceeds rapidly (normally 1 h) at room temperature in an environmentally benign solvent (EtOAc) with only a slight excess of the dehydrating agent (1.1 equiv). A broad scope of nitriles can be prepared, including chiral nonracemic ones. In addition, in a number of cases, further purification of the nitrile after the workup was not required.

THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS

Thiazolylphenyl-benzenesulfonamido derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.