16778-74-8Relevant academic research and scientific papers
METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)
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Page/Page column 155, (2011/11/01)
Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.
DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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Page/Page column 81, (2010/03/02)
A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
A convenient synthesis of 4,5-disubstituted 1,2,4-triazoles functionalized in position 3
Ivanova, Natalia V.,Sviridov, Sergey I.,Shorshnev, Sergey V.,Stepanov, Aleksander E.
, p. 156 - 160 (2007/10/03)
A convenient approach to 4,5-disubstituted 3-hydroxymethyl-1,2,4-triazoles as well as to the corresponding 3-chloromethyl and 3-carboxaldehyde derivatives was developed starting from 3-mercapto-1,2,4-triazoles which can, in turn, be readily obtained from
